Sökning: "coenzyme A"

Visar resultat 21 - 25 av 54 avhandlingar innehållade orden coenzyme A.

  1. 21. Short-chain dehydrogenases/reductases : structure, function and motifs of hydroxysteroid dehydrogenases

    Författare :Charlotta Filling; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Short-chain dehydrogenases reductases; site-directed mutagenesis; steady-state kinetics; X-ray structure; enzyme function; steroid; motif; reaction mechanism; 3 beta 17 beta-hydroxysteroid dehydrogenase; 17 beta-hydroxysteroid dehydrogenase; short chain hydroxyacyl coenzyme A dehydrogenase;

    Sammanfattning : Short-chain dehydrogenases/reductases (SDR) constitute a superfamily of proteins catalysing reactions of a wide range of substrates in all life forms. During the past years, a large number of new proteins belonging to this superfamily has been detected. They are important in e.g. LÄS MER

  3. 22. Hormonal regulation of hepatic cholesterol and lipoprotein metabolism : effects of estrogen and growth hormone

    Författare :Paolo Parini; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :aging; atherosclerosis; bile acids; estrogen; estrogen receptor; cholesterol; growth hormone; growth hormone receptor; cholesterol 7[alpha]-hydroxylase; high density lipoprotein; hydroxy-methylglutaryl-coenzyme A reductase; hormones; hypercholesterolemia; hypophysectomy; insulin-like growth factor-I; low density lipoproteins;

    Sammanfattning : Coronary heart disease is the result of the progression of atherosclerotic lesions, and represents the major cause of death in western countries. Age, male sex, plasma cholesterol, hypertension and smoking are major risk factors for atherosclerosis. LÄS MER

  4. 23. Structural enzymology of oxalate degradation in Oxalobacter formigenes

    Författare :Catrine L Berthold; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Oxalic acid, as one of nature's most highly oxidised compounds, is toxic to most organisms. It is introduced in the human body in the diet but also as a waste product of cellular metabolism. Mammals do not posses the ability to degrade oxalate and must excrete it in the urine or through the intestine. LÄS MER

  5. 24. Fighting Tuberculosis – : Structural Studies of Three Mycobacterial Proteins

    Författare :Alina Castell; Torsten Unge; Manfred Weiss; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Mycobacterium tuberculosis; Rv0216; Rv0130; Mycobacterium smegmatis; branched chain aminotransferase; X-ray crystallography; fatty acid metabolism; Structural biology; Strukturbiologi;

    Sammanfattning : This thesis presents the cloning, purification, crystallization, and structural studies of two unknown proteins from Mycobacterium tuberculosis, and of an aminotransferase from Mycobacterium smegmatis. Structural knowledge of these proteins is of highest interest for structure-based drug design, which is one of the approaches that can be used in order to fight tuberculosis (TB). LÄS MER

  7. 25. Bioinformatic methods in protein characterization

    Författare :Yvonne Kallberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Bioinformatic methods in protein characterization;

    Sammanfattning : Bioinformatics is an emerging interdisciplinary research field in which mathematics. computer science and biology meet. In this thesis. bioinformatic methods for analysis of functional and structural properties among proteins will be presented. LÄS MER