Sökning: "Short-chain dehydrogenases reductases"

Visar resultat 1 - 5 av 7 avhandlingar innehållade orden Short-chain dehydrogenases reductases.

  1. 1. Short-chain retinol dehydrogenases/reductases : Involvement in retinoid metabolism and expression in embryonic and adult mouse

    Författare :Paulina Tuvendal; Uppsala universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biosciences; -; Farmaceutisk biovetenskap; Biopharmacy; Biofarmaci; Toxicology; toxikologi;

    Sammanfattning : Retinoids are needed in the embryo to ensure proper development and in the adult forvision, maintenance of epithelia and sperm production. Retinol is oxidised within the cell generating retinal and, irreversibly, retinoic acid. LÄS MER

  3. 2. X-ray structure analysis of short-chain dehydrogenases/reductases

    Författare :Jordi Benach-Andreu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :crystal structure; short-chain dehydrogenases reductases; Drosophila alcohol dehydrogenase; catalytic reaction mechanism; Comamonas testosteroni 3[beta] 17[beta]hydroxysteroid dehydrogenase;

    Sammanfattning : X-ray crystallography and site-directed mutagenesis were used to better understand the structure/function relationships in the family of short-chain dehydrogenases/reductases (SDR). This group of enzymes constitutes a protein family with at least 60 members with highly diverse functions in pro- and eukaryotes. LÄS MER

  4. 3. Short-chain dehydrogenases/reductases : structure, function and motifs of hydroxysteroid dehydrogenases

    Författare :Charlotta Filling; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Short-chain dehydrogenases reductases; site-directed mutagenesis; steady-state kinetics; X-ray structure; enzyme function; steroid; motif; reaction mechanism; 3 beta 17 beta-hydroxysteroid dehydrogenase; 17 beta-hydroxysteroid dehydrogenase; short chain hydroxyacyl coenzyme A dehydrogenase;

    Sammanfattning : Short-chain dehydrogenases/reductases (SDR) constitute a superfamily of proteins catalysing reactions of a wide range of substrates in all life forms. During the past years, a large number of new proteins belonging to this superfamily has been detected. They are important in e.g. LÄS MER

  5. 4. Substrate specificities and functional properties of human short-chain dehydrogenases / reductases

    Författare :Sheikh Naeem Shafqat; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Short-chain dehydrogenases/reductases (SDRs) constitute a universal superfamily of functionally heterogeneous proteins and participate in the metabolism of steroids, prostaglandins, retinoids, aliphatic alcohols, and xenobiotics. So far, more than 3000 members including species variants and over 60 human SDR genes are deposited in databases. LÄS MER

  7. 5. Characterization of stress-inducible short-chain dehydrogenases/reductases (SDR) in plants : study of a novel small protein family from Pisum sativum (pea)

    Författare :Nikolai Scherbak; Åke Strid; Jan Rydström; Örebro universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; Cell biology; Biology; Biologi; Biology; Biologi;

    Sammanfattning : In pea (Pisum sativum), the short-chain alcohol dehydrogenase-like protein (SAD) gene family consists of at least three members (SAD-A, -B, and -C). The SAD genes are transiently expressed in plants after short exposures to ultraviolet-B radiation, which in turn leads to formation of SAD protein in leaf and stem tissue upon prolonged irradiation. LÄS MER