Sökning: "Rv0130"

Hittade 2 avhandlingar innehållade ordet Rv0130.

  1. 1. Fighting Tuberculosis – : Structural Studies of Three Mycobacterial Proteins

    Författare :Alina Castell; Torsten Unge; Manfred Weiss; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Mycobacterium tuberculosis; Rv0216; Rv0130; Mycobacterium smegmatis; branched chain aminotransferase; X-ray crystallography; fatty acid metabolism; Structural biology; Strukturbiologi;

    Sammanfattning : This thesis presents the cloning, purification, crystallization, and structural studies of two unknown proteins from Mycobacterium tuberculosis, and of an aminotransferase from Mycobacterium smegmatis. Structural knowledge of these proteins is of highest interest for structure-based drug design, which is one of the approaches that can be used in order to fight tuberculosis (TB). LÄS MER

  3. 2. Structural Studies of a Xyloglucan Endotransglycosylase from Populus tremula x tremuloides and Three Conserved Hypothetical Proteins from Mycobacterium tuberculosis

    Författare :Patrik Johansson; Alwyn Jones; Sherry Mowbray; Pedro Alzari; Uppsala universitet; []
    Nyckelord :Cell and molecular biology; xyloglucan endotransglycosylase; Mycobacterium tuberculosis; epoxide hydrolase; fatty acid metabolism; fatty acid oxidation; crystallography; Cell- och molekylärbiologi;

    Sammanfattning : This thesis describes the structural studies of four different proteins from two organisms. Xyloglucan endotransglycosylases, XETs, are involved in plant cell wall expansion and remodeling by splitting and reconnecting xyloglucan-cellulose crosslinks. The first crystal structure of a XET enzyme has been determined to 1.8 Å. LÄS MER