Sökning: "bile acids"

Visar resultat 1 - 5 av 102 avhandlingar innehållade orden bile acids.

1. 1. Cytochrome P450 Enzymes in Bile Acid Biosynthesis and Fatty Acid Metabolism : Studies on Members of the Porcine CYP4A and CYP8B Subfamilies

   Författare :Kerstin Lundell; Kjell Wikvall; Ronnie Hansson; Stefan Alexson; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biochemistry; cytochrome P450; bile acids; fatty acids; CYP4A; CYP8B; genome; porcine; hyocholic acid; Farmaceutisk biokemi; Pharmaceutical biochemistry; Farmaceutisk biokemi; farmaceutisk biokemi; Pharmaceutical Biochemistry;

   Sammanfattning : The present investigation is devoted to studies on porcine members of the cytochrome P450 4A (CYP4A) and CYP8B1 subfamilies, which are involved in bile acid biosynthesis and fatty acid metabolism. Hyocholic acid is considered to fulfil the requirements for trihydroxy bile acids in the domestic pig (Sus scrofa) in the absence of cholic acid. LÄS MER

3. 2. The interplay between bile acids and gut microbiota in metabolic and hepatobiliary disease

   Författare :Wilhelm Sjöland; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; gut microbiota; bile acids; type 2 diabetes; hepatobiliary disease; obesity; metabolic disease;

   Sammanfattning : The gut microbiota, a metabolic regulator, orchestrates the production of bioactive metabolites such as secondary bile acids. Growing evidence suggests that shifts in the gut microbiota composition are linked to metabolic and hepatobiliary disease. LÄS MER

4. 3. Regulation of bile acids by prebiotic food components : Studies in rat caecum and in serum of mice and humans

   Författare :Tannaz Ghaffarzadegan; Avdelningen för livsmedel och läkemedel; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Bile acids; Dietary fibre; Fat; Pectin; Guar gum; Barley; Lingonberry; Turmeric; Short-chain fatty acids; Gut microbiota; Caecum; Serum; Rat; Mice; Humans; GC-FID; UHPLC-MS;

   Sammanfattning : Bile acids (BA) are formed from cholesterol in the liver and, apart from being part of fat digestion, they also act as signalling molecules in several health-related physiological processes. BA composition is regulated by gut microbiota as well as dietary fibre (DF) and fat in the diet. LÄS MER

5. 4. Gut microbial regulation of bile acid metabolism and signaling

   Författare :Sama I. Sayin; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicine; Gut Microbiota; Bile Acids;

   Sammanfattning : The collection of microbes in our gastrointestinal tract, the gut microbiota, is an environmental factor that has profound impact on host health and disease. Bile acids are endogenous cholesterol-derived molecules that can be modified by the gut microbiota and function as signaling molecules in regulation of host metabolic processes. LÄS MER

7. 5. On the role of bile acids in chronic diarrhoea

   Författare :Kjell-Arne Ung; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Diarrhoea; bile acid malabsorption; steatorrhoea; collagenous colitis; lymphocytic colitis; cholestyramine; long-term; histopathology; symptoms; ileal resection;

   Sammanfattning : Bile acids which promote lipid absorption are actively reabsorbed in the distal ileum. Bile acid malabsorption (BAM) and microscopic colitis (lymphocytic and collagenous) are both associated with chronic watery diarrhoea. LÄS MER