Sökning: "Strukturbiologi"

Visar resultat 1 - 5 av 205 avhandlingar innehållade ordet Strukturbiologi.

  1. 1. Structural studies of proteins in apoptosis and lipid signaling

    Författare :Maria Dolores Herman Moreno; Pär Nordlund; Markus Gruetter; Stockholms universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; proteins; crystal structure; apoptosis; cancer; CoFi-Blot; kinases; lipid signaling; Structural biology; Strukturbiologi; Structural Biology; strukturbiologi;

    Sammanfattning : Signaling pathways control the fate of the cell. For example, they promote cell survival or commit the cell to death (apoptosis) in response to cell injury or developmental stimuli, decisions, which are vital for the proper development and functioning of metazoan. LÄS MER

  2. 2. Prediction of zinc-binding sites in proteins and efficient protein structure description and comparison

    Författare :Nanjiang Shu; Sven Hovmöller; Elisabeth Sauer-Eriksson; Alexander Luybartsev; Stockholms universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; zinc-binding; shape strings; protein structures; secondary structures; machine learning; Molecular biology; Molekylärbiologi; Biochemistry; Biokemi; Bioinformatics; Bioinformatik; Structural biology; Strukturbiologi; biokemi; Biochemistry; Structural Biology; strukturbiologi; Molecular Biology; molekylärbiologi;

    Sammanfattning : A large number of proteins require certain metals to stabilize their structures or to function properly. About one third of all proteins in the Protein Data Bank (PDB) contain metals and it is estimated that approximately the same proportion of all proteins are metalloproteins. LÄS MER

  3. 3. Computational Analysis of Molecular Recognition Involving the Ribosome and a Voltage Gated K+ Channel

    Författare :Martin Andér; Johan Åqvist; Lennart Nilsson; Uppsala universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; computer simulations; molecular dynamics; ligand binding; binding free energy; linear interaction energy; codon recognition; translation termination; release factor; voltage gated potassium ion channel; Kv1.5; Structural biology; Strukturbiologi; Biochemistry; Biokemi; Biokemi; Biochemistry;

    Sammanfattning : Over the last few decades, computer simulation techniques have been established as an essential tool for understanding biochemical processes. This thesis deals mainly with the application of free energy calculations to ribosomal complexes and a cardiac ion channel. LÄS MER

  4. 4. Fighting Tuberculosis – : Structural Studies of Three Mycobacterial Proteins

    Författare :Alina Castell; Torsten Unge; Manfred Weiss; Uppsala universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Mycobacterium tuberculosis; Rv0216; Rv0130; Mycobacterium smegmatis; branched chain aminotransferase; X-ray crystallography; fatty acid metabolism; Structural biology; Strukturbiologi;

    Sammanfattning : This thesis presents the cloning, purification, crystallization, and structural studies of two unknown proteins from Mycobacterium tuberculosis, and of an aminotransferase from Mycobacterium smegmatis. Structural knowledge of these proteins is of highest interest for structure-based drug design, which is one of the approaches that can be used in order to fight tuberculosis (TB). LÄS MER

  5. 5. Tunnels and Grooves : Structure-Function Studies in Two Disparate Enzymes

    Författare :Daniel Ericsson; Sherry Mowbray; Guy Dodson; Uppsala universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Mycobacterium tuberculosis; ribonucleotide reductase; peptide inhibitors; fluorescence polarization; lipase; interfacial activation; hydrolase; X-ray structure; substrate specificity; Structural biology; Strukturbiologi;

    Sammanfattning : This thesis describes structural and binding studies in enzymes from two different  organisms: ribonucleotide reductase from Mycobacterium tuberculosis (RNR) and lipase A from Candida antarctica (CalA).RNR is viable as a target for new drugs against the causative agent of tuberculosis. LÄS MER