Sökning: "clinical chemistry"

Visar resultat 36 - 40 av 250 avhandlingar innehållade orden clinical chemistry.

1. 36. Lifestyle, biomarkers and the risk of developing inflammatory bowel disease

   Författare :Lovisa Widbom; Johan Hultdin; Pontus Karling; Kim Ekblom; Kristina Stefansson; Andreas Münch; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Inflammatory bowel disease; ulcerative colitis; Crohn s disease; smoking; cotinine; iron deficiency; ferritin; pyridoxal-5-phosphate; kynurenine pathway; Clinical Chemistry; klinisk kemi; invärtesmedicin; Internal Medicine;

   Sammanfattning : Introduction: Inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn’s disease (CD), is a chronic disease causing inflammation in the gut mucosa. The pathogenesis involves alteration in gut microbiota and in the intestinal barrier due to genetic factors, environmental exposure and dysregulation of the immune response. LÄS MER

3. 37. Clinical aspects of restorative treatment in the primary dentition

   Författare :Mirja Varpio; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Child; Child; Preschool; Cohort Studies; Composite Resins; chemistry; DMF Index; Dental Caries; epidemiology; microbiology; pathology; therapy; Dental Cavity Preparation; classification; Dental Enamel; pathology; Dental Restoration; Permanent; statistics numerical data; Follow-Up Studies; Glass Ionomer Cements; chemistry; Humans; Molar; Prevalence; Prosthesis Failure; Recurrence; Sweden; epidemiology; Tooth; Deciduous;

   Sammanfattning : The failure rate of restorative treatment in primary teeth was studied in a cohort of children born in 1981 and related to caries diagnosis, prevalence and distribution on different tooth surfaces, and compared with a cohort of children born in 1971. Concurrently, the longevity of composite resin in modified Class 2 cavities in primary molars was followed up and the resistance of deciduous and permanent enamel to acid adjacent to composite resin and glass polyalkeonate cement (GPA) was tested in vitro. LÄS MER

4. 38. The informational value and usefulness of serum retinoid measurements. Studies on biological variation, including infancy and pregnancy, and influence of fasting, antiepileptic drugs and ethanol

   Författare :Maria Berggren Söderlund; Avdelningen för klinisk kemi och farmakologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Klinisk kemi; Clinical chemistry; vitamin A deficiency; teratogenicity; ethanol; antiepileptic drugs; caloric restriction; infant; pregnant; biological variation; 13-cis retinoic acid; all-trans retinoic acid; Vitamin A; retinol;

   Sammanfattning : The aims of these studies were to evaluate retinoid measurements, more specifically the performance of all-trans and 13-cis retinoic acids methods in clinical experimental settings and to evaluate the informational value of these measurements in relation to S-Retinol. Biological and analytical variations for retinoids were evaluated for healthy subjects. LÄS MER

5. 39. Bioanalysis using capillary electrophoresis and mass spectrometry : Applied on proteins, protein nanofibrils and polyvinyl alcohol microbubbles

   Författare :Leila Josefsson; Åsa Emmer; Ulrika Nilsson; KTH; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; : amyloid; capillary electrophoresis; contrast agents; detection; human blood plasma; ionic liquids; mass spectrometry; microbubbles; polyvinyl alcohol microbubbles; protein nanofibrils; proteins; Kemi; Chemistry;

   Sammanfattning : The sequencing of the genome of various species, including the human species, have led to increased understanding about how a protein structure is generated, and how specific structures are related to the proteins’ functionality. In paper I and II of this thesis, the folding of proteins in vitro to form hierarchical nanostructures, which in vivo often have a pathological effect, have been studied. LÄS MER

7. 40. Imaging of Enzymes in the Steroid Biosynthetic Pathway : Synthesis of 18F-Labelled Tracers

   Författare :Maria Erlandsson; Bengt Långström; Franklin Aigbirhio; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Organic chemistry; Organisk kemi; Organisk kemi; Organic Chemistry;

   Sammanfattning : This thesis deals with the synthesis and development of 18F-labelled alkyl etomidate and vorozole analogues, and their use as positron emission tomography (PET) tracers for the imaging of the steroid enzymes 11β-hydroxylase and aromatase. Two synthetic 18F-labelling approaches to the etomidate and vorozole analogues were developed, and the analogues were evaluated in some biological assays. LÄS MER