Sökning: "cleavage prediction"

Hittade 4 avhandlingar innehållade orden cleavage prediction.

  1. 1. Computational Prediction Models for Proteolytic Cleavage and Epitope Identification

    Detta är en avhandling från Department of Theoretical Physics, Lund University

    Författare :Liwen You; Högskolan i Halmstad.; Lunds universitet.; Lund University.; [2007]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; TECHNOLOGY Bioengineering Bioinformatics; TEKNIKVETENSKAP Bioteknik Bioinformatik; Binding affinity; Caspase; Cleavage predition; Cleavage specifictiy; Epitope; False positive; Gaussian process; HCV; Hierarchial method; HIV; Immunology; MHC; OSRE; Protease-peptide interaction; Rule extraction; Sequence analysis; SVM; medical informatics; biomathematics biometrics; sequence analysis; rule extraction; protease-peptide interaction; immunology; hierarchical method; false positive; epitope; cleavage specificity; cleavage prediction; binding affinity; caspase; medicinsk informatik; biomatematik; Computer science; numerical analysis; systems; control; Datalogi; numerisk analys; system; kontroll;

    Sammanfattning : The biological functions of proteins depend on their physical interactions with other molecules, such as proteins and peptides. Therefore, modeling the protein-ligand interactions is important for understanding protein functions in different biological processes. LÄS MER

  2. 2. Micromechanical modeling of cleavage fracture in polycrystalline materials

    Detta är en avhandling från Stockholm : KTH

    Författare :Mateusz Stec; KTH.; [2008]
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; cleavage fracture; probabilistic modeling; brittle to ductile transition; cohesive zone; visco-plastic material; TECHNOLOGY Engineering mechanics; TEKNIKVETENSKAP Teknisk mekanik; TECHNOLOGY Other technology; TEKNIKVETENSKAP Övriga teknikvetenskaper;

    Sammanfattning : Cleavage fracture in ferritic steels can be defined as a sequence of few critical steps. At first nucleation of a microcrack takes place, often in a hard inclusion. This microcrack then propagates into the surrounding matrix material. The last obstacle before failure is the encounter of grain boundaries. LÄS MER

  3. 3. Ab initio prediction of the mechanical properties of alloys

    Detta är en avhandling från Stockholm : KTH Royal Institute of Technology

    Författare :Guisheng Wang; KTH.; [2015]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Industriell ekonomi och organisation; Industrial Engineering and Management;

    Sammanfattning : At the time of the 50th anniversary of the Kohn-Sham method, ab initio calculations based on density functional theory have formed an accurate, efficient, and reliable method to work on the properties of engineering materials. In this thesis, we use the exact muffin-tin orbitals method combined with the coherent-potential approximation to study the mechanical properties of high-technology materials. LÄS MER

  4. 4. Modeling the Interaction Space of Biological Macromolecules: A Proteochemometric Approach Applications for Drug Discovery and Development

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Aleksejs Kontijevskis; Uppsala universitet.; [2008]
    Nyckelord :Bioinformatics; proteochemometrics; bioinformatics; chemoinformatics; chemical space; QSAR; retroviral proteases; HIV-1; drug resistance; pharmacogenomics; cytochrome P450; GPCRs; melanocortin receptors; interactome; machine-learning; rough sets; Bioinformatik;

    Sammanfattning : Molecular interactions lie at the heart of myriad biological processes. Knowledge of molecular recognition processes and the ability to model and predict interactions of any biological molecule to any chemical compound are the key for better understanding of cell functions and discovery of more efficacious medicines. LÄS MER