Sökning: "up-regulation"

Visar resultat 1 - 5 av 307 avhandlingar innehållade ordet up-regulation.

  1. 1. Molecular Mechanisms in Vascular Endothelin B Receptor Up-Regulation

    Författare :Erik Uddman; Lund Medicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Kardiovaskulära systemet; Cardiovascular system; reverse; in vitro pharmacology; organ culture; Endothelin receptors; up-regulation;

    Sammanfattning : Cardiovascular diseases are characterized by changes in morphology and function of the blood vessels. Different signalling molecules are involved in these changes. Endothelin-1 (ET-1) is one of the most potent signalling molecules found in man. Its actions are mediated by two receptors, the ETA and the ETB receptors. LÄS MER

  2. 2. Up-regulation of dopamine D₂ receptors : in vitro and in vivo studies

    Författare :Maria Wanderoy; Eliassitet Eriksson; Stockholms universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurochemistry; Neurokemi; neurokemi och neurotoxikologi; Neurochemistry and Neurotoxicology;

    Sammanfattning : In the central nervous system (CNS) dopaminergic and dopaminoceptive neurons have the ability to respond to variations in dopamine levels by for example adjusting their dopamine receptor levels. One of the most well known phenomena in this respect is that long-term blockade of D2 receptors with antipsychotic drugs leads to an increase in striatal D2 receptor density of experimental animals as well as of schizophrenic patients as measured in both post-mortem studies and in vivo positron emission tomography studies of brain. LÄS MER

  3. 3. Constraints on up-regulation of drug efflux in the evolution of ciprofloxacin resistance

    Författare :Lisa Praski Alzrigat; Diarmaid Hughes; Fernando Baquero; Uppsala universitet; []
    Nyckelord :ciprofloxacin; antibiotic resistance; drug efflux; bacterial fitness; marR; acrR; marA; experimental evolution; Mikrobiologi; Microbiology;

    Sammanfattning : The crucial role of antibiotics in modern medicine, in curing infections and enabling advanced medical procedures, is being threatened by the increasing frequency of resistant bacteria. Better understanding of the forces selecting resistance mutations could help develop strategies to optimize the use of antibiotics and slow the spread of resistance. LÄS MER

  4. 4. Therapy of neuroendocrine tumors with 177Lu-octreotate - Human tumor cell types and models and optimization of treatment : Terapi av neuroendokrina tumörer med 177Lu-octreotate

    Författare :Johanna Dalmo; Göteborgs universitet; Göteborgs universitet; Gothenburg University; Göteborgs universitet; Gothenburg University; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; somatostatin; radionuclide therapy; receptor up-regulation; RBP; nephrotoxicity;

    Sammanfattning : Neuroendocrine (NE) tumors (NET) have often metastasized at the time of diagnose, which makes it hard to cure patients with NET. Radiolabeled hormone analogues (especially somatostatin analogues, SS) can be used for diagnostics (e.g. 111In-octreotide) and therapy (e. LÄS MER

  5. 5. Top-down and bottom-up regulation of macroalgal communities – implications for coral reef management in Eastern Africa

    Författare :Erik Mörk; Stockholms universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Terrestrial; freshwater and marine ecology; Terrestisk; limnisk och marin ekologi;

    Sammanfattning : .... LÄS MER