Sökning: "blood–brain barrier"

Visar resultat 1 - 5 av 10 avhandlingar innehållade orden blood–brain barrier.

  1. 1. Development of new affinity proteins for neurodegenerative disorders

    Författare :Linnea C. Hjelm; John Löfblom; Stefan Ståhl; Hanna Lindberg; Ylva Ivarsson; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Protein engineering; sequestrins; amyloid beta; alpha-synuclein; phage display; affibodies; blood–brain barrier; Transferrin receptor; receptor-mediated transcytosis; recombinant spider silk; Biotechnology; Bioteknologi;

    Sammanfattning : Neurodegenerative disorders include a full spectrum of diagnoses, including dementias and other neuronal diseases, characterised by degradation of neurons in the brain occurring along with disease progression. Amongst the dementias, the most prevalent are Alzheimer’s (AD) and Parkinson’s disease (PD) that affect millions of people worldwide. LÄS MER

  3. 2. WAVELET NOISE REDUCTION AND VASCULAR WATER TRANSPORT MODELLING : APPLICATIONS TO DIFFUSION AND PERFUSION MRI

    Författare :Adnan Bibic; Lund Medicinsk strålningsfysik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cerebral blood flow; perfusion; diffusion; arterial spin labelling; wavelets; filtering; denoising; blood-brain barrier; permeability; Fysicumarkivet A:2018:Bibic;

    Sammanfattning : Magnetic resonance imaging (MRI) is a powerful medical imaging technique, used to detect and characterise a range of diseases and conditions. It is based on the use of a strong static magnetic field in combination with magnetic field gradients and pulsed radiofrequency electromagnetic fields to visualise various organs and structures in the body according to their morphology or function. LÄS MER

  4. 3. Fever : Role of brain endothelial prostaglandins

    Författare :Daniel Björk Wilhelms; David Engblom; Kazuhiro Nakamura; Linköpings universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : Fever and loss of appetite are two of the most fundamental manifestations of disease. These disease symptoms, which lead to deviations from normal body temperature and food intake patterns, are seen in a vast array of infectious and inflammatory conditions. LÄS MER

  5. 4. Human iPSC-based models of theCNS: attaining cellular biofidelitythrough conventional and advancedculture systems

    Författare :Dimitrios Voulgaris; Anna Herland; Susanna Narkhilakhi; KTH; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; neural stem cells; astrocytes; iPSC; hiAstrocytes; microphysiological systems; BBB; Bioteknologi; Biotechnology;

    Sammanfattning : Brain development is a highly orchestrated process that entails changes in microenvironmental cues and growth factor gradients, which set the tempo for proper development of the rudimentary structures of the brain and the generation of neurons,astrocytes, and oligodendrocytes. Another intricate feature of the brain is the bloodbrain barrier (BBB). LÄS MER

  7. 5. Designing thiophene-based fluorescent probes for the study of neurodegenerative protein aggregation diseases : From test tube to in vivo experiments

    Författare :Andreas Åslund; Peter Konradsson; Ian Nicholls; Linköpings universitet; []
    Nyckelord :TECHNOLOGY; TEKNIKVETENSKAP;

    Sammanfattning : Protein aggregation is an event related to numerous neurodegenerative diseases, such as Alzhemier’s disease and prion diseases. However little is known as to how and why the aggregates form and furthermore, the toxic specie may not be the mature fibril but an on route or off route specie towards mature aggregates. LÄS MER