Sökning: "permeability"

Visar resultat 1 - 5 av 600 avhandlingar innehållade ordet permeability.

  1. 1. Intestinal absorption of drugs : The impact of regional permeability, nanoparticles, and absorption-modifying excipients

    Författare :Carl Roos; Hans Lennernäs; Erik Sjögren; Martin Brandl; Uppsala universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Permeability; intestinal absorption; regional permeability; nanoparticles; nanosuspensions; absorption-modifying excipients; AMEs; Biofarmaci; Biopharmaceutics;

    Sammanfattning : For successful delivery of orally given drug products, the drug compounds must have adequate solubility and permeability in the human gastrointestinal tract. The permeability of a compound is determined by its size and lipophilicity, and is usually evaluated in various pre-clinical models, including rat models. LÄS MER

  2. 2. Function of granulocytes after burns and trauma, associations with pulmonary vascular permeability, acute respiratory distress syndrome, and immunomodulation

    Författare :Joakim Johansson; Folke Sjöberg; Lennart Lindbom; Sven-Erik Ricksten; Linköpings universitet; []
    Nyckelord :ARDS; azurocidin; burn; CAP-37; critical care; granulocyte; HBP; histamine; intensive care; leucocyte; leukocyte; mediator; methylhistamine; MOF; oedema; neutrophil; permeability; PMN; trauma; vascular permeability;

    Sammanfattning : Background: Our innate immunesystem protects us from infections but, since its methods is not all specific for microorganisms, may also induce collateral damage.Severe physical injury often proved deadly throughout evolution. Such injuries may induce massive collateral damage. LÄS MER

  3. 3. Intestinal permeability : a parameter of mucosal dysfunction

    Författare :Pål Lundin; Biologiska institutionen; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Peptide; N-acetylcysteine; Medium-chain glyceride; Mannitol; Macromolecules; Lipid; Kinetics; In vivo; In vitro; In situ; Intestine; Injury; Inflammation; HLA-B27; HCl; Epithelium; Enhancer; dDAVP; 51Cr-EDTA; BSA; Absorption; Albumin; Permeability; Animal physiology; Djurfysiologi;

    Sammanfattning : The gastrointestinal tract has two opposing functions; to absorb nutrients and electrolytes, and to act as a barrier towards hazardous and non-nutritional substances. In the present thesis the barrier function of the gastrointestinal tract was studied in animal models in vivo, in situ and in vitro. LÄS MER

  4. 4. Shaping Macroporous Ceramics : templated synthesis, X-ray tomography and permeability

    Författare :Linnéa Andersson; Lennart Bergström; Ludwig Gauckler; Stockholms universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; Alumina; ceramic; CO2 capture; colloidal processing; expandable microspheres; gel casting; layer-by-layer; macroporosity; near-net shape; non-destructive evaluation; permeability; porosity; sacrificial templating; X-ray computed tomography; Chemistry; Kemi; materialkemi; Materials Chemistry;

    Sammanfattning : Macroporous ceramic materials have found widespread technological application ranging from particulate filters in diesel engines, tissue engineering scaffolds, and as support materials in carbon capture processes. This thesis demonstrates how the pore space of macroporous alumina can be manipulated, analysed in three-dimensions (3D) using visualisation techniques, and functionalised with a CO2-adsorbing material. LÄS MER

  5. 5. Regulation of VEGFR2 signaling in angiogenesis and vascular permeability

    Författare :Chiara Testini; Lena Claesson-Welsh; Mats Hellström; Mauro Giacca; Uppsala universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICAL AND HEALTH SCIENCES; VEGFR2; angiogenesis; permeability; NRP1; Y949; Y1212; paladin; Molekylär medicin; Molecular Medicine;

    Sammanfattning : Angiogenesis and vascular permeability occur in physiological and pathological conditions. Angiogenesis denotes the process of blood vessel formation from preexisting quiescent vessels. LÄS MER