Sökning: "biological cost of resistance"

Visar resultat 6 - 10 av 34 avhandlingar innehållade orden biological cost of resistance.

1. 6. Development and Stability of Antibiotic Resistance

   Författare :Maria Sjölund; Lars Engstrand; Dan Andersson; Pentti Huovinen; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Microbiology; antibiotic resistance; selection; mutation frequency; biological cost of resistance; compensatory evolution; Helicobacter pylori; normal microbiota; Mikrobiologi; Microbiology; immunology; infectious diseases; Mikrobiologi; immunologi; infektionssjukdomar;

   Sammanfattning : Antibiotic resistance is of current concern. Bacteria have become increasingly resistant to commonly used antibiotics and we are facing a growing resistance problem. The present thesis was aimed at studying the impact of antibiotic treatment on pathogenic bacteria as well as on the normal human microbiota, with focus on resistance development. LÄS MER

3. 7. Costs in the ecology and evolution of the vertebrate immune system

   Författare :Lars Råberg; MEMEG; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; cost of resistance; ecological immunology; immunocompetence; Parus caeruleus; transgenic mice; Animal ecology; Djurekologi; blue tit; basal metabolic rate;

   Sammanfattning : A central assumption of theories of the ecology and evolution of immunological defence is that defence has not only benefits (in the form of resistance against parasites), but also costs. The aim of my studies was to investigate the nature and magnitude of costs of the vertebrate immune system, and to examine some of the consequences of these costs. LÄS MER

4. 8. Mechanisms and Biological Costs of Bacterial Resistance to Antimicrobial Peptides

   Författare :Hava Lofton Tomenius; Dan I Andersson; Ørjan Samuelsen; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; antimicrobial peptides; antibiotic resistance; fitness cost; Salmonella Typhimurium; Staphylococcus aureus; bile; serum; pH response; growth rate; mice; phoP; pmrB; waaY; LPS; LL-37; defensins; membrane potential; Mikrobiologi; Microbiology;

   Sammanfattning : The global increasing problem of antibiotic resistance necessarily drives the pursuit and discovery of new antimicrobial agents. Antimicrobial peptides (AMPs) initially seemed like promising new drug candidates. Already members of the innate immune system, it was assumed that they would be bioactive and non-toxic. LÄS MER

5. 9. Mutations and Mutation Rate in the Development of Fluoroquinolone Resistance

   Författare :Patricia Komp Lindgren; Diarmaid Hughes; Fernando Baquero; Uppsala universitet; []
   Nyckelord :Microbiology; Mutation rate; Fluoroquinolone; Resistance; Biological fitness; Urinary tract infection; Escherichia coli; MPC; Mikrobiologi;

   Sammanfattning : The emergence of multidrug resistant bacteria world wide is a serious problem, and very few new drugs are under development. The selection of resistant bacteria is affected by factors such as mutation rate, biological fitness cost and the rate of fitness compensation. LÄS MER

7. 10. Molecular Epidemiology and Mechanisms of Antibiotic Resistance in Clinical Isolates of Pseudomonas aeruginosa from Qatar

   Författare :Mazen Sid Ahmed; Jana Jass; Emad Ibrahim; Ali Sultan; Bo Söderquist; Christian Giske; Örebro universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Antibiotics; C T; CZA; MDR; Pseudomonas aeruginosa; ST235; VEB; VIM;

   Sammanfattning : Inappropriate and excessive use of antibiotics promotes antimicrobial resistance (AMR), particularly in Gram-negative bacteria (GNB). There is a noticeable increase in nosocomial infections caused by multidrug-resistant (MDR) Pseudomonas aeruginosa, which is associated with significant morbidity, mortality, and an increase in cost management. LÄS MER