Sökning: "LL-37"

Visar resultat 1 - 5 av 62 avhandlingar innehållade ordet LL-37.

  1. 1. LL-37-derived cyclic antimicrobial drug leads : Design, synthesis, activity and different ways of creating them 

    Författare :Taj Muhammad; Ulf Göransson; Sunithi Gunasekera; Adam A. Strömstedt; Wang Guangshun; Uppsala universitet; []
    Nyckelord :antimicrobial peptide; host defense; antimicrobial; LL-37; KR-12; peptide cyclisation; peptide dimerisation; croos-linking; cyanobactin-macrocyclase; PatGmac; butelase 1; enzymatic cyclisation; immobilisation; Farmakognosi; Pharmacognosy;

    Sammanfattning : In an era where last-line antibiotics are failing, one of the powerful approaches to develop novel therapeutic agents is to turn back to nature in order to identify possible drug candidates. Among the potential candidates, antimicrobial peptides (AMPs) have garnered much attention as an antimicrobial. LÄS MER

  2. 2. Effects of the host defense peptide LL-37 on human cells : Immunomodulation and cytotoxicity

    Författare :Sara Bodahl; Kärlfysiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; LL-37; Host defense peptides; Cathelicidin; Inflammation; Cytotoxicity; TLR3; Poly I:C;

    Sammanfattning : The human host defense peptide LL-37 has an essential role in the first line of defense against invading pathogens. This cathelicidin is mainly produced by immune cells and epithelial cells aligning the mucosal areas and is normally upregulated upon infection and inflammation. LÄS MER

  3. 3. Regulation of human cell viability by the host defence peptide LL-37

    Författare :Daniel Svensson; Kärlfysiologi; []
    Nyckelord :LL-37; cathelicidin; cytotoxicity; host defence peptides; autoimmune diseases; inflammation; vitamin D;

    Sammanfattning : Accumulating evidence suggests that the main human cathelicidin peptide, LL-37, may influence host cell viability and pro-inflammatory signaling when locally overexpressed. LL-37 has pro-inflammatory properties linked to the development of for example psoriasis, rosacea, SLE and atherosclerosis. LÄS MER

  4. 4. Functional dualism of antimicrobial host defence peptides

    Författare :Åse Björstad; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Nyckelord :antimicrobial; apoptosis; cathelicidin; host defence peptide; interleukin 8; LL-37; permeabilisation;

    Sammanfattning : Antimicrobial host defence peptides are central to innate immunity and many possess direct antimicrobial actions on bacteria as well as indirect immunomodulatory functions on human leukocytes. Different variants of the bifunctional Helicobacter pylori peptide, Hp(2-20), were synthesised and inhibition zone assays and chemiluminescence systems were employed for determination of direct antimicrobial action and superoxide release (immunomodulatory) from human neutrophils, respectively. LÄS MER

  5. 5. Pathogen-host interactions at the surface of Streptococcus pyogenes

    Författare :Patrik Nyberg; Infektionsmedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Infektioner; Infections; C3a; LL-37; antimicrobial peptide; GRAB; alpha-2-macroglobulin; proteolysis; SpeB; internalization; virulence; protein F1; Streptococcus pyogenes; fibronectin;

    Sammanfattning : The bacterial surface can be thought of as the interface where pathogenic bacteria encounter the human host. Interactions between bacterial surface proteins and human proteins are important determinants of the eventual outcome of infection. LÄS MER