Sökning: "biological cost of resistance"

Visar resultat 1 - 5 av 29 avhandlingar innehållade orden biological cost of resistance.

  1. 1. Multi-Resistance Plasmids Fitness Costs, Dynamics and Evolution

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Fredrika Rajer; Uppsala universitet.; [2019]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; multi-resistance plasmids; evolution; fitness cost; dynamics; escherichia coli; ESBL; gene amplification; β-lactamase inhibitor; Biologi med inriktning mot mikrobiologi; Biology with specialization in Microbiology;

    Sammanfattning : Antibiotic resistance is an escalating problem, not only due to less desirable treatment options and outcome, but also due to the economic burden to health care caused by resistant pathogens. Since the process of developing new antibiotics is slow, we need to carefully consider the usage of the antibiotics still available. LÄS MER

  3. 2. Mechanisms and Dynamics of Carbapenem Resistance in Escherichia coli

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Marlen Adler; Uppsala universitet.; [2014]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; carbapenem; antibiotic resistance; fitness cost; ESBLs; penicillin-binding proteins; gene amplification;

    Sammanfattning : The emergence of extended spectrum β-lactamase (ESBL) producing Enterobacteriaceae worldwide has led to an increased use of carbapenems and may drive the development of carbapenem resistance. Existing mechanisms are mainly due to acquired carbapenemases or the combination of ESBL-production and reduced outer membrane permeability. LÄS MER

  4. 3. The biological cost of resistance to antibiotics

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Johanna Björkman; Uppsala universitet.; [2000]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Cell and molecular biology; Cell- och molekylärbiologi; NATURAL SCIENCES Biology Cell and molecular biology; NATURVETENSKAP Biologi Cell- och molekylärbiologi; mikrobiologi; Microbiology;

    Sammanfattning : The rate of development and stability of antibiotic resistance are determined by several factors including (i) the mutation rate, (ii) the fitness costs of resistance, and (iii) the ability of bacteria to genetically compensate for such costs.. This study has focused on the experimental measurement of these parameters in antibiotic-resistant S. LÄS MER

  5. 4. Evolutionary Dynamics of Mutation and Gene Transfer in Bacteria

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Peter A Lind; Uppsala universitet.; [2010]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; fitness cost; bacterial evolution; gene amplification; mutational biases; GC content; synonymous substitutions; horizontal gene transfer; experimental evolution; MEDICINE Microbiology; immunology; infectious diseases Microbiology Bacteriology; MEDICIN Mikrobiologi; immunologi; infektionssjukdomar Mikrobiologi Bakteriologi; NATURAL SCIENCES Biology Organism biology Microbiology; NATURVETENSKAP Biologi Organismbiologi Mikrobiologi; NATURAL SCIENCES Biology Cell and molecular biology Genetics; NATURVETENSKAP Biologi Cell- och molekylärbiologi Genetik; NATURAL SCIENCES Biology; NATURVETENSKAP Biologi; Mikrobiologi; Microbiology;

    Sammanfattning : The study of bacterial evolution is fundamental for addressing current problems of antibiotic resistance and emerging infectious diseases and lays a solid foundation for successful and rational design in biotechnology and synthetic biology. The main aim of this thesis is to test evolutionary hypotheses, largely based on theoretical considerations and sequence analysis, by designing scenarios in a laboratory setting to obtain experimental data. LÄS MER

  7. 5. Defence and signalling in Potato-Phytophthora infestans interactions

    Detta är en avhandling från Department of Biology, Lund University

    Författare :Ashfaq Ali; Lund University.; Lunds universitet.; [2012]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Phytophthora infestans; Plant defence; hypersensitive response; resistance; susceptibility;

    Sammanfattning : Potato is one of the major food crops and its yield is severely affected by late blight disease caused by Phytophthora infestans. P. infestans has the ability to manipulate plant defence signalling by secreting effector molecules causing so called effector triggered susceptibility. LÄS MER