Sökning: "biological cost of resistance"

Visar resultat 1 - 5 av 28 avhandlingar innehållade orden biological cost of resistance.

  1. 1. Mechanisms and Dynamics of Carbapenem Resistance in Escherichia coli

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Marlen Adler; Uppsala universitet.; [2014]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; carbapenem; antibiotic resistance; fitness cost; ESBLs; penicillin-binding proteins; gene amplification;

    Sammanfattning : The emergence of extended spectrum β-lactamase (ESBL) producing Enterobacteriaceae worldwide has led to an increased use of carbapenems and may drive the development of carbapenem resistance. Existing mechanisms are mainly due to acquired carbapenemases or the combination of ESBL-production and reduced outer membrane permeability. LÄS MER

  2. 2. The biological cost of resistance to antibiotics

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Johanna Björkman; Uppsala universitet.; [2000]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Cell and molecular biology; Cell- och molekylärbiologi; NATURAL SCIENCES Biology Cell and molecular biology; NATURVETENSKAP Biologi Cell- och molekylärbiologi; mikrobiologi; Microbiology;

    Sammanfattning : The rate of development and stability of antibiotic resistance are determined by several factors including (i) the mutation rate, (ii) the fitness costs of resistance, and (iii) the ability of bacteria to genetically compensate for such costs.. This study has focused on the experimental measurement of these parameters in antibiotic-resistant S. LÄS MER

  3. 3. Evolutionary Dynamics of Mutation and Gene Transfer in Bacteria

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Peter A Lind; Uppsala universitet.; [2010]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; fitness cost; bacterial evolution; gene amplification; mutational biases; GC content; synonymous substitutions; horizontal gene transfer; experimental evolution; MEDICINE Microbiology; immunology; infectious diseases Microbiology Bacteriology; MEDICIN Mikrobiologi; immunologi; infektionssjukdomar Mikrobiologi Bakteriologi; NATURAL SCIENCES Biology Organism biology Microbiology; NATURVETENSKAP Biologi Organismbiologi Mikrobiologi; NATURAL SCIENCES Biology Cell and molecular biology Genetics; NATURVETENSKAP Biologi Cell- och molekylärbiologi Genetik; NATURAL SCIENCES Biology; NATURVETENSKAP Biologi; Mikrobiologi; Microbiology;

    Sammanfattning : The study of bacterial evolution is fundamental for addressing current problems of antibiotic resistance and emerging infectious diseases and lays a solid foundation for successful and rational design in biotechnology and synthetic biology. The main aim of this thesis is to test evolutionary hypotheses, largely based on theoretical considerations and sequence analysis, by designing scenarios in a laboratory setting to obtain experimental data. LÄS MER

  4. 4. Defence and signalling in Potato-Phytophthora infestans interactions

    Detta är en avhandling från Department of Biology, Lund University

    Författare :Ashfaq Ali; Lunds universitet.; Lund University.; [2012]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Phytophthora infestans; Plant defence; hypersensitive response; resistance; susceptibility;

    Sammanfattning : Popular Abstract in English Plants harvest sunlight to fix air carbon dioxide into a form which is the fundamental source of energy for other organisms such as animals. The domestication of crop plants and traditional breeding practices has resulted in increased yield and nutritional value of crops. LÄS MER

  5. 5. Biological and Pharmacological Factor that Influence the Selection of Antibiotic Resistance

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Ingegerd Gustafsson; Uppsala universitet.; [2003]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Microbiology; Human microflora; antibiotic resistance; selection; mutation frequency; biological fitness; pharmacokinetics; pharmacodynamics; β-lactam antibiotics; suboptimal dosing regimen; Mikrobiologi; NATURAL SCIENCES Biology Organism biology Microbiology; NATURVETENSKAP Biologi Organismbiologi Mikrobiologi; Klinisk bakteriologi; Clinical Bacteriology;

    Sammanfattning : Antibiotic treatment causes an ecological disturbance on the human microflora. Four commensal bacteria: E. coli, enterococci, a-streptococci and coagulase-negative staphylococci, from patients with extensive, high antibiotic usage were investigated with regard to resistance pattern and mutation frequency. LÄS MER