Sökning: "Fluoroquinolone"

Visar resultat 1 - 5 av 21 avhandlingar innehållade ordet Fluoroquinolone.

  1. 1. Mutations and Mutation Rate in the Development of Fluoroquinolone Resistance

    Författare :Patricia Komp Lindgren; Diarmaid Hughes; Fernando Baquero; Uppsala universitet; []
    Nyckelord :Microbiology; Mutation rate; Fluoroquinolone; Resistance; Biological fitness; Urinary tract infection; Escherichia coli; MPC; Mikrobiologi;

    Sammanfattning : The emergence of multidrug resistant bacteria world wide is a serious problem, and very few new drugs are under development. The selection of resistant bacteria is affected by factors such as mutation rate, biological fitness cost and the rate of fitness compensation. LÄS MER

  3. 2. Resistance to Fluoroquinolones in Escherichia coli: Prevention, Genetics and Fitness Costs

    Författare :Linda L. Marcusson; Diarmaid Hughes; Karl Drlica; Uppsala universitet; []
    Nyckelord :Biology; Fluoroquinolone; Escherichia coli; Resistance; Gyrase; Topoisomerase IV; MPC; Fitness compensation; Urinary Tract Infection; Biologi;

    Sammanfattning : Antibiotic-resistant bacteria are increasingly a major healthcare problem but very few new classes of antibiotics have been discovered or launched in recent decades. Approaches to dealing with the problem include learning how bacteria evolve to resistance and improving dosing regimens with current antibiotics so as to reduce the selection of resistant bacteria. LÄS MER

  4. 3. Computational studies of photodynamic drugs, phototoxic reactions and drug design

    Författare :Klefah Abrahem Klefah Musa; Leif Eriksson; Nino Russo; Örebro universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NSAIDs; fluoroquinolone; photodegradation; phototoxicity; drug design; DFT; TD-DFT; Biophysical chemistry; Biofysikalisk kemi; Chemistry; Kemi;

    Sammanfattning : The most important criterion when designing new drugs or improving old ones in order to prevent side effects or at least diminish them is drug safety. Treatment of all diseases generally needs use of either topical application or systemic medications (transported in the blood) during a certain period of time. LÄS MER

  5. 4. Pharmacoepidemiologic studies on antimicrobial safety

    Författare :Olof Nibell; Infektionsmedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; antibiotikabiverkningar; Antibiotics: adverse effects; Epidemiology; Epidemiologi; Fluoroquinolone; Fluorokinoloner; Macrolides; Makrolider; flucloxacillin; Flukloxacillin;

    Sammanfattning : .... LÄS MER

  7. 5. Molecular mechanisms of fluoroquinolone resistance in Pseudomonas aeruginosa

    Författare :Shah Jalal; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :quinolone resistance; P. aeruginosa; PCR; DNA sequencing; mutation; NIRCA; RESA; multidrug efflux; cystic fibrosis;

    Sammanfattning : Pseudomonas aeruginosa is an opportunistic nosocomial pathogen. In compromised human, it can cause infections in urinary tract, wound and respiratory tract such as pneumonia and progressive lung diseases. LÄS MER