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Visar resultat 1 - 5 av 36 avhandlingar som matchar ovanstående sökkriterier.

1. 1. Imaging brain aromatase by using PET : A way to study anabolic steroid abuse

   Författare :Kayo Takahashi; Mats Bergström; Bengt Långström; Yasuyoshi Watanabe; Torbjörn Bäckström; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; aromatase; brain; molecular imaging; PET; [11C]Vorozole; amygdala; hypothalamus; anabolic-androgenic steroids; abuse; [18F]Vorozole analogs; Neuroscience; Neurovetenskap;

   Sammanfattning : Aromatase is an enzyme that facilitates the conversion of androgens to estrogens and may play a role in mood and mental status. The main theme of this thesis is the imaging of brain aromatase by use of the PET technique. The PET tracer for aromatase, 11C-labeled vorozole (VOZ) was developed and evaluated by with in vitro and in vivo methods. LÄS MER

3. 2. Regulation of Ovarian Aromatase: Studies by Aromatase Assays in vitro and in vivo

   Författare :Dmitrijus Kirilovas; Mats Brännström; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Obstetrics and gynaecology; aromatase; human; granulosa cells; 11C-vorozole; active site; allosteric configuration; in vitro; in vivo; PET; androgens; rat; estrous cycle.; Obstetrik och kvinnosjukdomar; Obstetrics and women s diseases; Obstetrik och kvinnosjukdomar; Obstetrics and Gynaecology; obstetrik och gynekologi;

   Sammanfattning : An in vitro method was developed for measuring aromatase, based on binding of competitive aromatase inhibitor [11C]vorozole to the active site of the enzyme. [11C]Vorozole displayed high, specific binding in vitro to human placenta and human granulosa cells (GC), both fresh and frozen/thawed cells, provided correct procedures were used. LÄS MER

4. 3. Endocrine Disruption in Amphibians : Developmental Effects of Ethynylestradiol and Clotrimazole on the Reproductive System

   Författare :Irina Gyllenhammar; Cecilia Berg; Ingvar Brandt; Lena Holm; Joakim Larsson; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Test system; Xenopus tropicalis; Rana temporaria; sex ratio; sex differentiation; fertility; aromatase; ovary; testis; oviduct; Biology; Biologi;

   Sammanfattning : Amphibian populations are declining world-wide and one of the suggested reasons is environmental pollutants. Studies of long-term effects on the reproductive system in frogs following larval exposure to environmental pollutants are scarce. It is therefore important to develop methods to study developmental reproductive toxicity in amphibians. LÄS MER

5. 4. Body constitution, statin use, and tumor characteristics. Implications for prognosis

   Författare :Helga Tryggvadottir; Epidemiologi och farmakogenetik; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; breast cancer; prognosis; tumor-specific markers; HMG-CoA reductase; aryl hydrocarbon receptor; aromatase; statins; anthropometric factors;

   Sammanfattning : Breast cancer is an important cause of disease-burden and death in women. To prevent over- and undertreatment of breast cancer patients, new prognostic and predictive factors are needed. LÄS MER

7. 5. Azoles and Contaminants in Treated Effluents Interact with CYP1 and CYP19 in Fish

   Författare :Kristina Beijer; Ingvar Brandt; Björn Brunström; Henner Hollert; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Azole; fungicide; chemical; CYP1A; CYP19; EROD; aromatase; effluent; STP; wastewater; fish; stickleback; rainbow trout; Biologi med inriktning mot ekotoxikologi; Biology with specialization in Environmental Toxicology;

   Sammanfattning : Numerous contaminants are present in mixtures in the aquatic environment. Among these are the azoles, a group of chemicals that includes both pharmaceuticals and pesticides. Azole fungicides are designed to inhibit lanosterol 14-demethylase (cytochrome P450 (CYP) 51), while other azoles are intended to inhibit aromatase (CYP19), i.e. LÄS MER