Sökning: "CYP1A"

Visar resultat 1 - 5 av 17 avhandlingar innehållade ordet CYP1A.

  1. 1. Interactions between cytochrome P450 and estrogenic compounds in fish

    Författare :Linda Hasselberg; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cytochrome P450; CYP1A; CYP3A; glutathione; alkylphenols; ethynylestradiol; ketoconazole; vitellogenin; Atlantic cod; rainbow trout; fish;

    Sammanfattning : DISSERTATION ABSTRACT Hasselberg, Linda. Interactions between cytochrome P450 and estrogenic compounds in fish. Department of Zoophysiology, Göteborg University, Box 463, SE-405 30 Göteborg, Sweden Contamination by various pollutions is an environmental concern. LÄS MER

  2. 2. A Gill Filament EROD Assay : Development and Application in Environmental Monitoring

    Författare :Maria Jönsson; Ingvar Brandt; Björn Brunström; Kristian Ingebrigtsen; Håkan Olsén; Uppsala universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; Biology; aquatic; benzo[a]pyrene; biomarker; CYP1A; environmental monitoring; EROD; fish; gill; indigo; PCB; Biologi; Biology; Biologi;

    Sammanfattning : A gill filament-based assay for the cytochrome P450 1A (CYP1A)-catalysed activity ethoxyresorufin O-deethylase (EROD) was developed in rainbow trout (Oncorhynchus mykiss) and applied to Atlantic salmon (Salmo salar), Arctic charr (Salvelinus alpinus), Atlantic cod (Gadus morhua), saithe (Pollachius virens), and spotted wolffish (Anarhichas minor). Exposure to waterborne β-naphthoflavone (βNF; 10-6 M) induced branchial EROD activity in all species but the spotted wolffish. LÄS MER

  3. 3. Azoles and Contaminants in Treated Effluents Interact with CYP1 and CYP19 in Fish

    Författare :Kristina Beijer; Ingvar Brandt; Björn Brunström; Henner Hollert; Uppsala universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; Azole; fungicide; chemical; CYP1A; CYP19; EROD; aromatase; effluent; STP; wastewater; fish; stickleback; rainbow trout; Biologi med inriktning mot ekotoxikologi; Biology with specialization in Environmental Toxicology;

    Sammanfattning : Numerous contaminants are present in mixtures in the aquatic environment. Among these are the azoles, a group of chemicals that includes both pharmaceuticals and pesticides. Azole fungicides are designed to inhibit lanosterol 14-demethylase (cytochrome P450 (CYP) 51), while other azoles are intended to inhibit aromatase (CYP19), i.e. LÄS MER

  4. 4. Chemical mixtures and interactions with detoxification mechanisms and biomarker responses in fish

    Författare :Johanna Gräns; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Nyckelord :Fish; AhR; CYP1A; PXR; Chemical mixtures; Chemical interaction; Biomarker;

    Sammanfattning : Several classes of anthropogenic chemicals are present as mixtures in the aquatic environment. However, information of how wildlife species, including fish, are affected by exposures to chemical mixtures is limited. LÄS MER

  5. 5. Gill EROD Activity in Fish : A Biomarker for Waterborne Ah-receptor Agonists

    Författare :Alexandra Abrahamson; Ingvar Brandt; Björn Brunström; Janneche Utne Skaare; Uppsala universitet; []
    Nyckelord :Biology; biomarker; fish; gill; CYP1A; EROD; environmental monitoring; induction; inhibition; PAH; PCB; produced water; Biologi;

    Sammanfattning : Induction of the cytochrome P450(CYP)1A protein and the connected increase in 7-ethoxyresorufin O-deethylase (EROD) activity are common biomarkers in fish. Enhanced activity of this protein signals exposure to Ah-receptor agonists such as chlorinated dioxins, co-planar polychlorinated biphenyls (PCBs) and certain polycyclic aromatic hydrocarbons (PAHs). LÄS MER