Sökning: "tumor-specific markers"

Visar resultat 1 - 5 av 15 avhandlingar innehållade orden tumor-specific markers.

  1. 1. Body constitution, statin use, and tumor characteristics. Implications for prognosis

    Författare :Helga Tryggvadottir; Epidemiologi och farmakogenetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; breast cancer; prognosis; tumor-specific markers; HMG-CoA reductase; aryl hydrocarbon receptor; aromatase; statins; anthropometric factors;

    Sammanfattning : Breast cancer is an important cause of disease-burden and death in women. To prevent over- and undertreatment of breast cancer patients, new prognostic and predictive factors are needed. LÄS MER

  3. 2. Natural and induced idiotype immunity in patients with multiple myeloma

    Författare :Lotta Hansson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Myeloma; idiotype; vaccination; GM-CSF; IL-12; clonal B cells; T cell epitopes; signal transduction molecules; activation markers;

    Sammanfattning : There is a great need for development of new treatment alternatives for patients with multiple myeloma (MM). The idiotype (Id) immunoglobulin (Ig) expressed by the myeloma B cell clone might be regarded as a tumor specific antigen and as such a target for immunotherapy. LÄS MER

  4. 3. High-risk breast cancer: From biology to personalized therapeutic strategies

    Författare :Toshima Z Parris; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; breast cancer; outcome prediction; molecular biomarker; 8p11-p12 amplification;

    Sammanfattning : Adjuvant treatment regimens for breast cancer are primarily based on patient- and tumor-related factors, e.g. patient menopausal status, tumor stage and histological grade, and the status of molecular tumor markers (HER2/neu and the estrogen receptor). LÄS MER

  5. 4. Statistical assessment of somatic mutations and genomic variability using DNA sequence data

    Författare :Anna Rehammar; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; DNA sequence data; exome sequencing; calling of somatic mutations; metagenomics; hierarchical Bayesian model; genomic variability; calling of somatic mutations;

    Sammanfattning : The development of new DNA sequencing techniques have made it possible to generate high-resolution genomic data at an unprecedented pace. However, the high dimensionality in combination with the substantial levels of technical errors and biological variability make the analysis challenging. LÄS MER

  7. 5. Stem cell based therapy of malignant brain tumors

    Författare :Daniel Bexell; Sektion IV; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neural stem cell; pericyte; mesenchymal stem cell; neuroblast; subventricular zone; cancer stem cell; rat; glioma; cancer;

    Sammanfattning : Malignant brain tumor is a highly invasive and vascularized cancer. Current forms of therapy are not curative and can, at best, prolong survival for patients with this disease. The mean survival is only around 15 months. LÄS MER