Sökning: "molecular imaging"

Visar resultat 1 - 5 av 470 avhandlingar innehållade orden molecular imaging.

  1. 1. Imaging the molecular pathways of neurodegeneration : New pathologies of SCA7

    Författare :Frida Niss; Anna-Lena Ström; Einar Hallberg; Georg Auberger; Stockholms universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurodegeneration; SCA7; Polyglutamine diseases; RNA binding proteins; Aggregation; Stress granules; Chromatin organization; Quantitative image analysis; Nuclear envelope; Nuclear pore complex; Nucleocytoplasmic transport; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

    Sammanfattning : Spinocerebellar Ataxia type 7 (SCA7) is a genetic neurodegenerative disease with lethal outcome that affects the cerebellum and retina of patients. This thesis focuses on characterising molecular pathological pathways that cause toxicity and cell death in SCA7. LÄS MER

  2. 2. Abdominal Aortic Aneurysm : Molecular Imaging Studies of Pathophysiology

    Författare :Gustaf Tegler; Anders Wanhainen; Martin Björck; Jens Sörensen; Lars Norgren; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Abdominal aortic aneurysm; AAA; Positron emission tomography; PET; Molecular Imaging; Pathophysiology; Autoradiography; Angiogenesis; integrin alphaVbeta3; FDG; 18F-FDG; 11C-PK11195; 11C-D-deprenyl; [18F]fluciclatide; Fluciclatide; Bukaortaaneurysm; Molekylär bilddiagnostik; Patofysiologi; PET; Autoradiografi; Angiogenes; Surgery; Kirurgi; Medicinsk radiofysik; Medical Radiophysics;

    Sammanfattning : The pathological process behind abdominal aortic aneurysm (AAA) formation is poorly understood and difficult to study. The aim of the thesis was to study the pathophysiology of AAA formation with positron emission tomography (PET) technology, a molecular imaging technique, allowing in vivo studies of pathophysiological changes. LÄS MER

  3. 3. Coherent Diffractive Imaging with X-ray Lasers

    Författare :Max Felix Hantke; Filipe R. N. C. Maia; Janos Hajdu; Martin Svenda; Edgar Weckert; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; coherent diffractive X-ray imaging; lensless imaging; coherent X-ray diffractive imaging; flash diffractive imaging; single particle imaging; aerosol injection; electrospray injection; substrate-free sample delivery; carboxysome; phase retrieval; X-ray diffraction software; X-ray free-electron laser; XFEL; FEL; CXI; CDI; CXDI; FXI;

    Sammanfattning : The newly emerging technology of X-ray free-electron lasers (XFELs) has the potential to revolutionise molecular imaging. XFELs generate very intense X-ray pulses and predictions suggest that they may be used for structure determination to atomic resolution even for single molecules. LÄS MER

  4. 4. Preclinical Molecular Imaging using Multi-Isotope Digital Autoradiography - Techniques and Applications

    Författare :Anders Örbom; Lund Medicinsk strålningsfysik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Autoradiography; Radioimmunotherapy; Antibodies; Molecular Imaging; Multi-Radionuclide Imaging; Silicon-strip detector;

    Sammanfattning : Molecular imaging, both in vivo and ex vivo, is playing an increasingly important role in preclinical medical research. When using radionuclide-labeled tracers, e.g. in the development of radiopharmaceuticals for diagnostic imaging or for radionuclide therapy, quantitative in vivo imaging can be performed using emission tomography. LÄS MER

  5. 5. Engineering of Affibody molecules for Radionuclide Molecular Imaging and Intracellular Targeting

    Författare :Camilla Hofström; Torbjörn Gräslund; Serge Muyldermans; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Affibody molecules; affinity proteins; radionuclide molecular imaging; intracellular targeting; EGFR; HER2; IGF-1R; SRA - Molecular Bioscience; SRA - Molekylär biovetenskap;

    Sammanfattning : Affibody molecules are small (7 kDa) affinity proteins of non-immunoglobulin origin that have been generated to specifically interact with a large number of clinically important molecular targets.In this thesis, Affibody molecules have been employed as tracers for radionuclide molecular imaging of HER2- and IGF-1R-expressing tumors, paper I-IV, and for surface knock-down of EGFR, paper V. LÄS MER