Sökning: "TNF"

Visar resultat 6 - 10 av 639 avhandlingar innehållade ordet TNF.

  1. 6. Development of molecular recognition by rational and combinatorial engineering

    Författare :Andreas Jonsson; Stefan Ståhl; Mats Persson; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Affibody molecule; albumin binding domain; protein engineering; phage display; amyloid beta peptide; TNF; HSA; Molecular biology; Molekylärbiologi;

    Sammanfattning : Combinatorial protein engineering, taking advantage of large libraries of protein variants and powerful selection technology, is a useful strategy for developing affinity proteins for applications in biotechnology and medicine. In this thesis, two small affinity proteins have been subjected to combinatorial protein engineering to improve or redirect the binding. LÄS MER

  3. 7. Adult Neural Stem Cells-Influence of Stroke, Inflammation and Aging

    Författare :Henrik Ahlenius; Lund Neurologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; inflammation; Neural stem cells; adult; neurogenesis; stroke; aging; TNF-R1; TNF-α;

    Sammanfattning : Neural stem cells (NSCs) in the embryo generate neurons, astrocytes and oligodendrocytes, the principal cells of the central nervous system (CNS), which contribute to the full diversity of the brain. Some NSCs persist in the adult brain and ensures neurogenesis throughout adult life in the subventricular zone (SVZ) and the subgranular zone (SGZ). LÄS MER

  4. 8. Candidate Genes for Late Diabetic Complications

    Författare :Eero Lindholm; diabetes och endokrinologi Genomik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TNF; sekretion; LTA; Endocrinology; nephropathy; diabetes mellitus; retinopathy; neuropathy; genetic; UCP; diabetologi; AGER; MHc2TA; HLA-DQB1; Endokrinologi; secreting systems; diabetology;

    Sammanfattning : Diabetes mellitus is a group of metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion, insulin action, or both. The new WHO criteria for classification of diabetes takes into account also clinical stages dividing the diabetic patients into noninsulin requiring (NIR), insulin requiring for control (IRC) and insulin requiring for survival (IRS) subgroups. LÄS MER

  5. 9. Modulaton of gene expression in human aortic smooth muscle cells by Porphyromonas gingivalis : a possible association between periodontitis and atherosclerosis

    Författare :Boxi Zhang; Torbjörn Bengtsson; Allan Sirsjö; Hazem Khalaf; Julia Davies; Örebro universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Microarray; Angiopoietin; Smooth muscle cells; TNF; Periodontitis; Atherosclerosis; Porphyromonas gingivalis; Cancer; Inflammasome; Biomedicin; Biomedicine;

    Sammanfattning : Porphyromonas gingivalis is a gram-negative, rod-shaped, and anaerobic bacterium that is involved in the pathogenesis of periodontitis. P. gingivalis produces a variety of virulence factors including gingipains and fimbriae. LÄS MER

  7. 10. Diabetic Vascular Complications & Inflammation - role of NFAT and TNFalpha

    Författare :Jenny Öhman; Kardiovaskulär forskning - immunitet och ateroskleros; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; vascular; hyperglycemia; osteopontin; NFAT; diabetes; retinopathy; TNF; UTP;

    Sammanfattning : Vascular complications of diabetes account for the majority of morbidity and mortality among diabetic patients. Large clinical trials have identified hyperglycemia as a risk factor in the development of diabetic vascular complications. LÄS MER