Sökning: "TNF"

Visar resultat 21 - 25 av 639 avhandlingar innehållade ordet TNF.

1. 21. Studies of molecular mechanisms of action of TNF antagonists in rheumatoid arthritis

   Författare :Anca Irinel Catrina; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Rheumatoid arthritis; TNF antagonists; cytokines; macrophages; matrix metalloproteinases; osteoprotegerin; RANKL; apoptosis;

   Sammanfattning : Rheumatoid arthritis (RA) is a common chronic inflammatory disease characterized by progressive bone destruction that leads to joint deformity and physical disability. Even though several therapeutic drugs are available, none have emerged as an ideal RA treatment that delays joint destruction and halts disease progression. LÄS MER

3. 22. Cytokine induced airway hyperreactivity characterized in an in-vitro model of asthma

   Författare :Yaping Zhang; Klinisk och experimentell allergiforskning; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; toxicology; Farmakologi; farmakognosi; MAPK; TNF-alpha; 5-HT; Respiratory system; Andningsorganen; Pharmacological sciences; pharmacognosy; pharmacy; interleukin-1beta; hyperresponsiveness; endothelin-1; airway; bradykinin; toxikologi; farmaci;

   Sammanfattning : Asthma is a chronic disorder of the lower airways, characterized by inflammation and hyperreactivity. Pro-inflammatory cytokines like tumour necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) are known to play important roles in the pathogenesis, but our knowledge how these cytokines contribute to the development of airway hyperreactivity is limited. LÄS MER

4. 23. Measure for measure. Outcome assessment of arthritis treatment in clinical practice

   Författare :Anders Gülfe; Reumatologi och molekylär skelettbiologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TNF blockade; rheumatoid arthritis; utility; treatment continuation; agreement; health related quality of life; Outcome; response; psoriatic arthritis; spondyloarthritis; disease activity; observational study;

   Sammanfattning : Objective: To investigate (i) the performance and agreement between various activity indices and response criteria in TNF-blockade of RA; (ii) the predictive ability of different response criteria and disease activity states regarding continuation of anti-TNF treatment of RA; (iii) Euro-QoL-5-dimensions utility development during TNF blockade of RA, PsA and SpA. Also, (iv) to develop a simple, utility-based outcome measure, the number needed to treat per quality adjusted life year gained (NNQ) and apply it in RA, PsA and SpA patients on anti-TNF treatment. LÄS MER

5. 24. On the role of mast cells in chemokine-induced leukocyte recruitment

   Författare :Yusheng Wang; Kirurgi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; chemokines; mast cells; TNF-alpha; dexamethasone; P-selectin; E-selectin; activation; Medicine human and vertebrates ; endothelial cells; adhesion; Neutrophil; Medicin människa och djur ; recruitment;

   Sammanfattning : Leukocyte recruitment is considered to playa key role in numerous inflammatory diseases. Tissue accumulation of Jeukocytes is a multi-steps process comprising rolling, adhesion and transmigration. LÄS MER

7. 25. Molecular targets for glucocorticoids in macrophages: cytosolic phospholipase A2 and cytokine formation

   Författare :Karin Gewert; Infektionsmedicin; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pharmacognosy; Pharmacological sciences; signal transduction; dexamethasone; cytosolic phospholipase A2; glucocorticoids; macrophages; protein kinase C; mitogen-activated protein kinases; TNF-alpha; IL-1beta; protein phosphatases; okadaic acid; pharmacy; toxicology; Farmakologi; farmakognosi; farmaci; toxikologi;

   Sammanfattning : The aim of this investigation has been to study mechanisms by which glucocorticoids inhibit inflammatory processes in vitro. Type IV cytosolic 85 kDa phospholipase A2 (cPLA2) is an important modulator of inflammatory responses that is present in macrophages as well as in other cell types. LÄS MER