Sökning: "Systemic lupus erythematosus SLE"

Visar resultat 31 - 35 av 130 avhandlingar innehållade orden Systemic lupus erythematosus SLE.

  1. 31. On the etiology and pathogenesis of systemic lupus erythematosus with special reference to environmental factors

    Författare :Anders Bengtsson; Reumatologi och molekylär skelettbiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; muscle system; rheumatology locomotion; Skelett; muskelsystem; reumatologi; Skeleton; Risk factors; Human parvovirus B19; Immune complex; Disease activity; Interferon-alpha; SLE; Retrovirus;

    Sammanfattning : Systemic lupus erythematosus (SLE) is a complex autoimmune disease in which environmental factors interact with genetic factors in the development of the disease process and evolution of clinical manifestations. In this thesis both exogenous factors and host factors were investigated, as well as important immunopathological aspects including involvement of immune complex (IC), the complement system and interferon-alpha (IFN-α). LÄS MER

  3. 32. Systemic Lupus Erythematosus, with focus on vascular wall changes, cardiac risk-factor awareness and cardiovascular events

    Författare :Christine Bengtsson; Reumatologi och molekylär skelettbiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; microvascular reactivity; arteria stiffness; cardiac risk factors; Cardiovascular event; SLE;

    Sammanfattning : Systemic Lupus Erythematosus is an autoimmune disease with a wide range of disease manifestations with respect to severity and magnitude of organ involvement. An increased risk of cardiovascular disease (CVD) compared with the general population causes both morbidity and mortality in SLE patients. LÄS MER

  4. 33. Immunological mechanisms in systemic autoimmunity : autoantibodies and chemokines in systemic lupus erythematosus and during treatment with TNF inhibitors in rheumatoid arthritis

    Författare :Catharina Eriksson; Karl-Gösta Sundqvist; Solbritt Rantapää-Dahlqvist; Mari Norgren; Thomas Skogh; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; autoimmunity; chemokines; T-cells; autoantibodies; CD91; Clinical immunology; Klinisk immunologi; Rheumatology; Reumatologi; Clinical Immunology; klinisk immunologi; reumatologi; rheumatology;

    Sammanfattning : Background. Rheumatoid Arthritis (RA) is an autoimmune inflammatory disease that, without powerful treatment, may lead to irreversible joint damage. During the past decade, anti-cytokine therapy has become available, e.g. LÄS MER

  5. 34. Lupus Nephritis – Genetic Impact on Clinical Phenotypes, Disease Severity and Renal Outcome

    Författare :Karin Bolin; Gunnel Nordmark; Lars Rönnblom; Inger Gjertsson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Systemic Lupus Erythematosus; Nephritis; Lupus Nephritis; Genetics; STAT4; BANK1; C1q Deficiency; Renal Insufficiency; End-Stage Renal Disease; Sex Differences; Medicinsk vetenskap; Medical Science;

    Sammanfattning : Systemic lupus erythematosus (SLE) is an autoimmune inflammatory disease that can affect every organ system. Lupus nephritis (LN) is one of the more serious SLE manifestations. Whilst the genetic background of SLE has been thoroughly investigated, less is known about the background of LN. LÄS MER

  7. 35. Defining the genetics of systemic autoimmunity in mouse models of lupus

    Författare :Katarina Haraldsson; Kristina Lejon; Dwight Kono; Chandra Mohan; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; SLE; susceptibility; HgIA; genome-wide mapping; Lbw2; Lmb1-4; suppressing gene; Immunology; Immunologi;

    Sammanfattning : Systemic Lupus Erythematosus (SLE) is a chronic multi-organ autoimmune disease considered a prototype for autoantibody and immune complex-mediated tissue injury. Although autoantibodies against a wide diversity of self-antigens are characteristically found in this disease, an important hallmark is the presence of autoantibodies to nuclear antigens. LÄS MER