Sökning: "Systemic lupus erythematosus SLE"

Visar resultat 11 - 15 av 130 avhandlingar innehållade orden Systemic lupus erythematosus SLE.

1. 11. Genetic Mapping of Susceptibility Genes for Systemic Lupus Erythematosus

   Författare :Bo Johanneson; Jean Pierre Hugot; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Molecular genetics; Association analysis; Candidate gene; Complex disease; Genome scan; Linkage analysis; Mapping; Susceptibility genes; Systemic lupus erythematosus; Genetik; Genetics; Genetik; medicinsk genetik; Medical Genetics;

   Sammanfattning : Systemic lupus erythematosus (SLE) is a complex autoimmune disease with unknown etiology. The aim of this thesis was to identify susceptibility regions through genetic mapping, using model-based linkage analysis on nuclear and extended SLE multicase families. LÄS MER

3. 12. Osteoporosis in SLE

   Författare :Katarina Almehed; Göteborgs universitet; []
   Nyckelord :osteoporosis; systemic lupus erythematosus; bone mineral density; health-related quality of life; SF-36; resistin; cross sectional study; vertebral fracture;

   Sammanfattning : As the treatment of Systemic Lupus Erythematosus (SLE) has become more effective the focus has partly shifted from main concern of short term morbidity and survival to long term complications such as osteoporosis. The aims of this thesis were to a) determine prevalence and risk factors of osteoporosis and of b) vertebral fractures c) evaluate if adequate osteoporotic treatment was provided d) determine if resistin, an adipokine with proposed pro-inflammatory properties, was associated with markers of inflammation or bone mineral density (BMD) and to e) investigate patients self reported health related quality of life (HRQOL) and its relationship to disease variables and employment status in female SLE patients. LÄS MER

4. 13. Genetic Contributions to Manifestations and Prognosis of Systemic Lupus Erythematosus

   Författare :Sarah Reid; Dag Leonard; Timothy Niewold; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Systemic lupus erythematosus; genetics; cardiovascular disease; polygenic risk score; smoking; Medicinsk vetenskap; Medical Science;

   Sammanfattning : Systemic lupus erythematosus (SLE) is a severe autoimmune disease with a multifactorial aetiology and an extremely heterogenous clinical picture. This thesis explores the impact of SLE genetic variants, through their cumulative effect or gene-environment interactions, on SLE manifestations and complications. LÄS MER

5. 14. Cardiovascular disease in systemic lupus erythematosus

   Författare :Elisabet Svenungsson; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Premature cardiovascular disease (CVD) is a major cause of morbidity and mortality in systemic lupus erythematosus (SLE). This is an important clinical problem and a main objective of this study was to identify risk factors and underlying mechanisms. LÄS MER

7. 15. Susceptibility genes in systemic lupus erythematosus

   Författare :Anna Hellquist; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Systemic lupus erythematosus (SLE) is a complex autoimmune disease for which the incidence and prevalence vary between populations and also between males and females. SLE is characterized by production of pathogenic autoantibodies against nuclear antigens due to a breakdown in self-tolerance and the pathogenesis is associated with the formation of immune complexes, followed by tissue inflammation in multiple organs, such as the skin, joints, heart and kidneys. LÄS MER