Sökning: "Systemic lupus erythematosus SLE"

Visar resultat 41 - 45 av 130 avhandlingar innehållade orden Systemic lupus erythematosus SLE.

  1. 41. Endogenous Type I Interferon Inducers in Systemic Autoimmune Diseases

    Författare :Tanja Lövgren; Lars Rönnblom; Gunnar Alm; Maija-Leena Eloranta; Andrej Tarkowski; Uppsala universitet; []
    Nyckelord :Medicine; Systemic lupus erythematosus; Sjögren s syndrome; type I interferon; plasmacytoid dendritic cell; natural interferon-producing cell; immune complex; RNP; Ro SSA; La SSB; Medicin;

    Sammanfattning : Patients with systemic lupus erythematosus (SLE) have elevated levels of interferon (IFN)-α in blood and IFN-α-producing cells in tissues. In the present thesis, we investigate the mechanisms behind the upregulated IFN-α-production in SLE and also show that the IFN-α system is activated in primary Sjögren’s syndrome (pSS), with IFN-α-producing cells in the major affected organ, the salivary glands. LÄS MER

  3. 42. When systemic lupus erythematosus (SLE) involves pain : occurrence and impact on daily life

    Författare :Eva Waldheim; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Living with a rheumatic disease, such as systemic lupus erythematosus (SLE), can pose many challenges. SLE is commonly considered to be a chronic disease, often occurring in unpredictable flares with alternating low and high disease activity. The disease predominantly affects women, but incidence and prevalence differ across different populations. LÄS MER

  4. 43. Novel immunological mechanisms and factors in systemic lupus erythematosus-related cardiovascular disease

    Författare :Anna Cederholm; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Systemic lupus erythematosus; cardiovascular disease; atherosclerosis; atherothrombosis; antiphospholipid antibodies; Annexin A5;

    Sammanfattning : Systemic Lupus Erythematosus (SLE) is a clinical syndrome of autoimmune origin. It manifests in diverse clinical and serological patterns and is considered to represent a prototype multisystemic autoimmune disease. The etiopathigenesis of SLE remains incompletely understood. LÄS MER

  5. 44. Exploring the Genetics of SLE with Linkage and Association Analysis

    Författare :Cecilia Johansson; Marta Alarcón-Riquelme; Peter Gregersen; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Molecular genetics; Systemic lupus erythematosus; complex disease; linkage analysis; association analysis; Genetik; Genetics; Genetik;

    Sammanfattning : The aim with this thesis has been to identify genes involved in the pathogenesis of Systemic Lupus Erythematosus (SLE). SLE is a systemic autoimmune disorder, most likely caused by both several genetic and environmental factors. LÄS MER

  7. 45. The activation and regulation of plasmacytoid dendritic cells in SLE : and possible therapeutic interventions

    Författare :Karin Hjorton; Lars Rönnblom; Maija-Leena Eloranta; Hans Carlsten; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; SLE; pDCs; NK cells; interferon; autoantibodies; immune complex; hydroxychloroquine; IRAK4 inhibition;

    Sammanfattning : Systemic Lupus Erythematosus (SLE) is an autoimmune disease, characterized by the presence of anti-nuclear antibodies and the formation of nucleic acid containing immune complexes (ICs), which can cause organ damage by deposition in tissues. ICs strongly trigger the plasmacytoid dendritic cells (pDCs) to produce interferon (IFN)-α, which potently activates the immune system. LÄS MER