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Visar resultat 16 - 20 av 201 avhandlingar som matchar ovanstående sökkriterier.

1. 16. Chondrocyte-matrix interactions: with emphasis on the collagen binding integrin a10ß1

   Författare :Lisbet Camper; Lunds universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; muscle system; Skeleton; chondrocyte; integrin; cartilage; chondroadherin; collagen; Biochemistry; metabolism; Biokemi; reumatologi; muskelsystem; Skelett; rheumatology locomotion;

   Sammanfattning : The work in this thesis has been focused on chondrocyte integrins and their interaction with the matrix proteins chondroadherin (CHAD) and collagen type II (CII). Affinity purification of CHAD-binding proteins from chondrocyte lysate, followed by immunoprecipitation of EDTA-eluted material identified alpha2beta1 as a CHAD-binding integrin. LÄS MER

3. 17. Development and application of strategies for the analysis of modification patterns in chondroitin and dermatan sulphate

   Författare :Fang Cheng; Institutionen för experimentell medicinsk vetenskap; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; reumatologi; muskelsystem; Skelett; Glycosaminoglycan; Proteoglycan; Chondroitin sulphate; dermatan sulphate; Sequencing analysis; Modification pattern.; Skeleton; rheumatology locomotion; muscle system; Metabolism; Biokemi; metabolism;

   Sammanfattning : Chondroitin (CS) and dermatan sulphate (DS) are socalled glycosaminoglycans (GAG) that are covalently attached to various type of proteins forming a subgroup within the diverse proteoglycan (PG) family. The PGs studied in this thesis are mostly extracellularly located and include aggrecan, biglycan and decorin. LÄS MER

4. 18. T cells in Autoimmunity: studies on murine type II collagen-induced arthritis

   Författare :Alexandre Corthay; Immunologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immunologi; Autoimmunity T lymphocytes collagen-induced arthritis Glycosylation TCR; transplantation; serology; Immunology; serologi; Skeleton; muscle system; rheumatology locomotion; Skelett; muskelsystem; reumatologi;

   Sammanfattning : Collagen-induced arthritis (CIA) is a mouse model for rheumatoid arthritis, in which autoimmunity is induced by immunization with type II collagen (CII), a cartilage-specific protein. In the present work, alpha/beta T cells were shown to be required for CIA and for the production of anti-CII IgG antibodies, whereas gamma/delta T cells were neither necessary nor sufficient for development of CIA. LÄS MER

5. 19. Inflammatory Response in Peripheral Arterial Disease

   Författare :Peter Danielsson; Malmö Institutionen för kliniska vetenskaper; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; muskelsystem; reumatologi; rheumatology locomotion; Skelett; Skeleton; Polymorphism; Metabolism; Prostacyclin; Microdislysis; Diabetes mellitus; Revascularisation; Angioplasty; Endothelial cells; White blood cells; Inflammation; Peripheral Arterial Disease; muscle system;

   Sammanfattning : Peripheral arterial disease (PAD) is the manifestation of atherosclerotic lesions in arteries supplying blood to the legs. Atherosclerosis is now recognized as an inflammatory disease of the vessel wall and important features in the pathophysiology are activation of WBC, endothelial cells and increased levels of inflammatory mediators. LÄS MER

7. 20. CHRONIC MUSCULOSKELETAL PAIN. Population studies of pain-experience with special focus on the Total Body Pain and aspects of adaptation in a cognitive-behavior psychological frame of reference

   Författare :John Ektor-Andersen; Kliniskt Centrum för Hälsofrämjande Vård; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Skeleton; muscle system; rheumatology locomotion; Skelett; muskelsystem; reumatologi; widespread; vocational dysfunction; sick leave; prediction; psychosocial factors; population study; pain; musculoskeletal; mechanical exposure; epidemiology; Chronic; coping; cognitive-behavioral psychology;

   Sammanfattning : Musculoskeletal pain-related vocational dysfunction is a major public health problem. The solution is beyond the scope of biomedicine, but the problem could well be analyzed in the complementary, cognitive-behavior psychological frame of reference. LÄS MER