Sökning: "dermatan sulphate"

Visar resultat 1 - 5 av 8 avhandlingar innehållade orden dermatan sulphate.

  1. 1. Development and application of strategies for the analysis of modification patterns in chondroitin and dermatan sulphate

    Författare :Fang Cheng; Institutionen för experimentell medicinsk vetenskap; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; reumatologi; muskelsystem; Skelett; Glycosaminoglycan; Proteoglycan; Chondroitin sulphate; dermatan sulphate; Sequencing analysis; Modification pattern.; Skeleton; rheumatology locomotion; muscle system; Metabolism; Biokemi; metabolism;

    Sammanfattning : Chondroitin (CS) and dermatan sulphate (DS) are socalled glycosaminoglycans (GAG) that are covalently attached to various type of proteins forming a subgroup within the diverse proteoglycan (PG) family. The PGs studied in this thesis are mostly extracellularly located and include aggrecan, biglycan and decorin. LÄS MER

  3. 2. Biosynthesis of Dermatan Sulphate. Enzymatic mechanism and role of cytokines

    Författare :Kerstin Tiedemann; Institutionen för experimentell medicinsk vetenskap; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Dermatan sulphate; 4-O-sulfotransferase; Co-polymeric structure; biglycan; decorin; Biochemistry; Biokemi; C5-epimerase; Metabolism;

    Sammanfattning : Dermatan sulphate is a prominent feature of several different proteoglycans and occurs in almost every tissue of the body. It is an unbranched polymer containing the repeating disaccharide unit of N-acetylgalactosamine and D-glucuronic acid or L-iduronic acid. LÄS MER

  4. 3. On the binding of growth-promoting polyamines to proteoglycans: Implications for growth-regulation and polycation-mediated gene transfer

    Författare :Mattias Belting; Institutionen för experimentell medicinsk vetenskap; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; cationic lipid.; gene transfer; gene therapy; cell growth; polyamine transport; spermine; polyamine; growth-inhibition; heparan sulphate; dermatan sulphate; Proteoglycan; glycosaminoglycan; cytogenetics; Genetik; cytogenetik;

    Sammanfattning : Initial investigations were directed at studying the interaction between polyamines and various glycosaminoglycans (GAGs). The polyamine spermine displayed binding to dermatan sulphate (DS) and heparan sulphate (HS) with similar (Kd, 3.9 x 10-4 M) and higher (Kd, 0.37 x 10-6 M) affinity, respectively, than to DNA. LÄS MER

  5. 4. The uterine proteoglycan expression in pregnancy and labor

    Författare :Ann Hjelm Cluff; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Labor; dysfunctional labor; heparan sulphate proteoglycans; syndecans; glypicans; perlecans; decorin; connexin 43; gap junctions; myometrial contractions;

    Sammanfattning : Objective: Protracted labor is a common clinical problem causing maternal and fetal complications. It is the leading indication for caesarean sections throughout the world, and emphasizes our need to be able to control labor. LÄS MER

  7. 5. Naphthoxylosides Investigations into glycosaminoglycan biosynthesis

    Författare :Mårten Jacobsson; Centrum för analys och syntes; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Organisk kemi; proteoglycan; Organic chemistry; nucleophilic aromatic substitution; thioether; glycosaminoglycan; xylosides; naphthoxylosides;

    Sammanfattning : Glycosaminoglycans (GAGs) are members of a family of polysaccharide structures consisting mostly of repeating disaccharide units. Most GAGs are attached to specific serine residues in proteins to form proteoglycans (PGs). LÄS MER