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Visar resultat 21 - 25 av 372 avhandlingar som matchar ovanstående sökkriterier.

1. 21. The Use of Laboratory Analyses in Sweden : Quality and Cost-Effectiveness in Test Utilization

   Författare :Mirja Mindemark; Anders Larsson; Lars-Olof Hansson; Per Simonsson; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; continuing medical education; cost control; cost savings; physician practice patterns; diagnostic tests; clinical chemistry; primary health care; health care costs; laboratory management; test utilization; trends; cost-effectiveness; inflammatory bowel disease; irritable bowel syndrome; calprotectin; cost avoidance; Clinical chemistry; Klinisk kemi; Biomedical Laboratory Science; Biomedicinsk laboratorievetenskap;

   Sammanfattning : Laboratory analyses, essential in screening, diagnosis, treatment, and monitoring of disease, are indispensable in health care, but appropriate utilization is intricate. The overall aim of this thesis was to study the use of laboratory tests in Sweden with the objective to evaluate and optimize test utilization. LÄS MER

3. 22. Extreme Value Analysis of Huge Datasets: Tail Estimation Methods in High-Throughput Screening and Bioinformatics

   Författare :Dmitrii Zholud; Göteborgs universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Extreme Value Statistics; High-Throughput Screening; HTS; Bioinformatics; analysis of huge datasets; quality control; correction of theoretical p-values; comparison of pre-processing methods; SmartTail; estimation of False Discovery Rates; test power; distribution tail; high level excursions; quantile estimation; multiple testing; Student t−test; Welch statistic; small sample sizes; F−test; Wiener process; Gaussian random walk; Shepp statistic; limit theorems; exotic options.; estimation of False Discovery Rates;

   Sammanfattning : This thesis presents results in Extreme Value Theory with applications to High-Throughput Screening and Bioinformatics. The methods described here, however, are applicable to statistical analysis of huge datasets in general. The main results are covered in four papers. LÄS MER

4. 23. Self-sampling for HPV testing in primary cervical screening : Including clinical and health economic aspects

   Författare :Riina Aarnio; Matts Olovsson; Ulf B. Gyllensten; Ingrid Wikström; Christer Borgfeldt; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; HPV; self-sampling; cervical screening; CIN2 ; cost-effectiveness; Obstetrik och gynekologi; Obstetrics and Gynaecology;

   Sammanfattning : Persistent infection with high-risk human papillomavirus (HPV) is a prerequisite for the development of cervical cancer. HPV testing has higher sensitivity for high-grade cervical intraepithelial neoplasia (CIN2+) than cytology, resulting in more effective screening. LÄS MER

5. 24. Mass screening for celiac disease in 12-year-olds : Finding them and then what?

   Författare :Anna Rosén; Anneli Ivarsson; Olof Sandström; Hans Stenlund; Maria Emmelin; Claes Hallert; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; adolescent; celiac disease; children; coeliac disease; focus groups; mass screening; qualitative methodology; questionnaire; transglutaminase antibodies; Epidemiology; epidemiologi; folkhälsa; Public health;

   Sammanfattning : Background Mass screening for celiac disease (CD) as a public health intervention is controversial. Before implementation, a suitable screening strategy should be outlined, and the acceptability of the screening scrutinized. Also, the benefits of early detection and possible negative consequences should be explored and compared. LÄS MER

7. 25. Toxicometabolomics and biotransformation product screening in single zebrafish embryos

   Författare :Anton Ribbenstedt; Jonathan P. Benskin; Magnus Breitholtz; Elena Gorokhova; Emma Schymanski; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Non-target; REACH; Orbitrap; single embryo; zebrafish embryo; metabolism; high throughput; hydroxylation; glucuronidation; metabolite screening; phase I; phase II; pharmaceutical; structure elucidation; conjugation; propranolol; beta blocker; Non-targeted; toxicometabolomics; Orbitrap; single embryo; 3R; metabolomics; MoA; mode of action; zebrafish embryo; carbamazepine; biotransformation; Applied Environmental Science; tillämpad miljövetenskap;

   Sammanfattning : Over the last decade environmental agencies worldwide have escalated their work to phase out animal testing for the purposes of chemical regulation. Meanwhile the number of commercially available chemicals and the requirements for hazard assessments have both increased, creating a large need for substitution of traditional in vivo assays with in vitro tests. LÄS MER