Sökning: "Non-targeted"

Visar resultat 1 - 5 av 26 avhandlingar innehållade ordet Non-targeted.

1. 1. Data analysis of non-targeted mass spectrometry experiments

   Författare :Erik Tengstrand; Magnus Åberg; Olav Kvalheim; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Analytical chemistry; Chemometrics; mass spectrometry; HPLC; metabolomics; Analytical Chemistry; analytisk kemi;

   Sammanfattning : Data processing tools are valuable to the analytical chemist as they can speed up the analysis, and sometimes solve problems that are not feasible to solve in a traditional manner. However, the complexity of many data processing tools can make their use daunting for the inexperienced user. LÄS MER

3. 2. Toxicometabolomics and biotransformation product screening in single zebrafish embryos

   Författare :Anton Ribbenstedt; Jonathan P. Benskin; Magnus Breitholtz; Elena Gorokhova; Emma Schymanski; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Non-target; REACH; Orbitrap; single embryo; zebrafish embryo; metabolism; high throughput; hydroxylation; glucuronidation; metabolite screening; phase I; phase II; pharmaceutical; structure elucidation; conjugation; propranolol; beta blocker; Non-targeted; toxicometabolomics; Orbitrap; single embryo; 3R; metabolomics; MoA; mode of action; zebrafish embryo; carbamazepine; biotransformation; Applied Environmental Science; tillämpad miljövetenskap;

   Sammanfattning : Over the last decade environmental agencies worldwide have escalated their work to phase out animal testing for the purposes of chemical regulation. Meanwhile the number of commercially available chemicals and the requirements for hazard assessments have both increased, creating a large need for substitution of traditional in vivo assays with in vitro tests. LÄS MER

4. 3. Removal processes in sewage treatment plants : Sludge quality and treatment efficiency of structurally diverse organic compounds

   Författare :Ulrika Olofsson; Peter Haglund; Staffan Lundstedt; Juliane Hollender; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Environmetrics; flame retardants; GCxGC; non-targeted screening; mass flow; metals; plasticizers; poorly removed contaminants; POP; PPCP; prediction; Principal Component Analysis; removal efficiency; sewage; sewage treatment plants; sludge; sludge adsorption; sources; time-trend analysis; Environmental chemistry; Miljökemi;

   Sammanfattning : Large and ever-increasing numbers of chemicals, including large quantities of a broad spectrum of organic compounds are used in modern society. More than 30 000 of the more than 100 000 chemical substances registered in the EU are estimated to be daily used, of which many will be discharged into the waste-streams handled by municipal sewage treatment plants (STPs). LÄS MER

5. 4. Advances in Mass Spectrometry for the Analysis of Emerging Persistent Organic Pollutants

   Författare :Lauren Gayle Mullin; Leo W. Y. Yeung; Ingrid Ericson Jogsten; Jean-François Focant; Örebro universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Mass Spectrometry; Liquid Chromatography; Supercritical Fluid Chromatography; Ion Mobility; POPs; Electrospray Ionization;

   Sammanfattning : Mass spectrometry (MS) is a technique widely implemented for the measurement of environmental pollutants. A critical tool for the analysis of persistent organic pollutants (POPs) over several decades, MS as coupled with liquid and gas chromatography (LC and GC) techniques enables the analysis of emerging POPs. LÄS MER

7. 5. Metabolic alterations and adipose tissue dysfunction in individuals with a family history of type 2 diabetes

   Författare :Josefin Henninger; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Typ 2 diabetes; Fettvävnadsdysfuntion; Förstagradssläktningar;

   Sammanfattning : ABSTRACT Aims The overall aim of this doctoral thesis was to further examine the anthropometric, metabolic and adipose tissue dysfunctions, as well as explore novel metabolites, associated with type 2 diabetes mellitus (T2D), examining individuals both with and without known genetic predisposition to T2D. This thesis is part of the research conducted at Lundberg laboratory for diabetes research, Institute of Medicine, Sahlgrenska Academy, at Gothenburg University. LÄS MER