Sökning: "propranolol"

Visar resultat 1 - 5 av 41 avhandlingar innehållade ordet propranolol.

  1. 1. Enantioselective Binding of Designed Propranolol Analogues to the Cellobiohydrolase Cel7A

    Författare :Alexandra Fagerström; Centrum för analys och syntes; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Strukturkemi; Structure chemistry; enzymologi; Proteiner; enzymology; Proteins; Naturvetenskap; Natural science; capillary electrophoresis; chiral recognition; enantiomeric selectivity; cellobiohydrolase Cel7A; propranolol; Organic chemistry; Organisk kemi;

    Sammanfattning : This thesis describes the affinity and enantiomeric selectivity of the cellobiohydrolase Cel7A (isolated from Hypocrea jercorina). The chiral recognition of the enzyme has been studied with respect to amino alcohols and new ligands have been designed, based on the structure of the common ?-blocker propranolol. LÄS MER

  3. 2. Stereoselective Transport of Drugs Across the Blood-Brain Barrier (BBB) In Vivo and In Vitro : Pharmacokinetic and Pharmacodynamic Studies of the (S)- and (R)-Enantiomers of Different 5-HT1A Receptor Agonists and Antagonists

    Författare :Hongmei Yan; Lennart Paalzow; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurosciences; pindolol; propranolol; 2- di-n-propylamino tetralin; racemate; enantiomer; drug distribution; brain; rat; blood-brain barrier; Neurovetenskap; Neurology; Neurologi; Psychiatry; psykiatri;

    Sammanfattning : Delivery of drugs to the brain requires passage across the blood-brain barrier (BBB). Both for drugs already on the market and for new drugs under development, it is important to know to what extent a drug enters the CNS. Many drugs used clinically are racemic mixtures, i.e. LÄS MER

  4. 3. Inflammation and immunothrombosis in cerebral cavernous malformation : Novel molecular targets for the treatment of an incurable disease

    Författare :Maria Ascención Globisch; Peetra Magnusson; Elisabetta Dejana; Marie Jeansson; Anna Randi; Uppsala universitet; []
    Nyckelord :Cavernoma; Inflammation; Coagulation; Blood-brain-barrier; Blood; Hypoxia; Propranolol; Biologi med inriktning mot molekylär immunologi; Biology with specialization in Molecular Immunology;

    Sammanfattning : Cerebral cavernous malformation (CCM) is a vascular disease that causes mulberry-like lesions (cavernomas) in the central nervous system (CNS). Cavernomas are fragile, leaky and prone to rupture which may cause symptoms such as epileptic seizures, focal neurological deficits and hemorrhagic strokes. CCM lesions can appear sporadically in 0. LÄS MER

  5. 4. Nano- and Micro-sized Molecularly Imprinted Polymer Materials for Analytical Application

    Författare :Keiichi Yoshimatsu; Tillämpad biokemi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; spin-coating; solid-phase extraction; composite; electrospinning; precipitation polymerisation; Enkephalin; fluorescent labelling; propranolol; nanoparticles; scintillation proximity assay; Molecular imprinting; Molecularly imprinted polymers; nanofibers; thin-film; microspheres;

    Sammanfattning : Specific molecular recognition materials are important in analytical applications. It has been a longstanding dream for scientific explorers to realise a versatile method to generate materials that can recognize biological and chemical substance of interests. LÄS MER

  7. 5. Toxicometabolomics and biotransformation product screening in single zebrafish embryos

    Författare :Anton Ribbenstedt; Jonathan P. Benskin; Magnus Breitholtz; Elena Gorokhova; Emma Schymanski; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Non-target; REACH; Orbitrap; single embryo; zebrafish embryo; metabolism; high throughput; hydroxylation; glucuronidation; metabolite screening; phase I; phase II; pharmaceutical; structure elucidation; conjugation; propranolol; beta blocker; Non-targeted; toxicometabolomics; Orbitrap; single embryo; 3R; metabolomics; MoA; mode of action; zebrafish embryo; carbamazepine; biotransformation; Applied Environmental Science; tillämpad miljövetenskap;

    Sammanfattning : Over the last decade environmental agencies worldwide have escalated their work to phase out animal testing for the purposes of chemical regulation. Meanwhile the number of commercially available chemicals and the requirements for hazard assessments have both increased, creating a large need for substitution of traditional in vivo assays with in vitro tests. LÄS MER