Sökning: "Ulf B. Gyllensten"

Hittade 4 avhandlingar innehållade orden Ulf B. Gyllensten.

  1. 1. Self-sampling for HPV testing in primary cervical screening : Including clinical and health economic aspects

    Författare :Riina Aarnio; Matts Olovsson; Ulf B. Gyllensten; Ingrid Wikström; Christer Borgfeldt; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; HPV; self-sampling; cervical screening; CIN2 ; cost-effectiveness; Obstetrik och gynekologi; Obstetrics and Gynaecology;

    Sammanfattning : Persistent infection with high-risk human papillomavirus (HPV) is a prerequisite for the development of cervical cancer. HPV testing has higher sensitivity for high-grade cervical intraepithelial neoplasia (CIN2+) than cytology, resulting in more effective screening. LÄS MER

  3. 2. Targeted Long-read Sequencing : Development and Applications in Medical Genetics

    Författare :Ida Höijer; Ulf B. Gyllensten; Adam Ameur; Lars Feuk; Winston Timp; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; long-read sequencing; targeted sequencing; targeted enrichment; CRISPR-Cas9; off-targets; medical genetics; repeat expansion; structural variant;

    Sammanfattning : Targeted sequencing has the advantage of providing pinpointed DNA information, while costs and data-analysis efforts are reduced. If targeted sequencing is combined with single molecule long-read sequencing, it can become a powerful tool to investigate genomic regions traditionally difficult using the predominantly used short-read sequencing platforms, including repetitive regions and large structural variants. LÄS MER

  4. 3. Exploring Biological Systems using Spatial Transcriptomic Technologies

    Författare :Kim Thrane; Joakim Lundeberg; Patrik Ståhl; Ulf Gyllensten; KTH; []
    Nyckelord :Spatial Transcriptomics; single-cell RNA-seq; scRNA-seq; spatial VDJ; Spatial Isoform Transcriptomics; Biotechnology; Bioteknologi;

    Sammanfattning : The transcriptome and the cells’ spatial organization are important determinants for the functions of biological systems, such as a tumor, brain, or skin tissue. Single-cell RNA sequencing (scRNA-seq) has emerged as a powerful tool for profiling the transcriptome of individual cells. LÄS MER

  5. 4. Identifying Risk Genes for Cervical Cancer : Using Affected Sib-Pairs and Case-Control Materials from Sweden

    Författare :Malin Engelmark; Ulf Gyllensten; Dan Holmberg; Uppsala universitet; []
    Nyckelord :Medicine; Cervical cancer; HPV; Affected sib-pairs; HLA; Fas; Genomewide scan; 9q32; TSCOT; Medicin;

    Sammanfattning : Cervical cancer is a multifactorial disease. Infection by oncogenic types of the human papillomavirus (HPV) is the major environmental risk factor and host genetic susceptibility also influences disease development. The aim of this thesis is to identify and analyse risk genes involved in the genetic predisposition to cervical carcinoma. LÄS MER