Sökning: "Retrovirus"

Visar resultat 31 - 35 av 46 avhandlingar innehållade ordet Retrovirus.

  1. 31. Roles of p16INk a and PDGF-B in glioma

    Författare :Lene Uhrbom; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; autocrine; glioma; INK4a; PDGF; Genetik; Clinical genetics; Klinisk genetik; Pathology; patologi;

    Sammanfattning : Gliomas are diffuse astrocytic tumors of the central nervous system (CNS) which usually affect adults. This thesis work has focused on molecular mechanisms of altered growth control in glioma, and the significance of two gene products belonging to pathways commonly affected in glioma, p16INK4a and PDGF-B, has been investigated in vitro and in vivo. LÄS MER

  3. 32. Synaptic Integration of Hippocampal Neurons Generated in the Adult Brain: Influence of a Pathological Environment

    Författare :Katherine Jakubs; Lund Neurologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neuropsykologi; neurofysiologi; Neurologi; synaptic plasticity; GABA; glutamate; GFP; Neurology; neuropsychology; neurophysiology; hippocampus; dentate gyrus; neurogenesis; LPS; inflammation; epilepsy; SE; patch-clamp;

    Sammanfattning : The adult brain constantly produces new neurons from endogenous neural progenitor cells located in at least two regions, the subgranular zone (SGZ) in dentate gyrus of the hippocampus, and the subventricular zone (SVZ). Major efforts are underway to discover the functional significance of new neurons in the adult brain. LÄS MER

  4. 33. Establishment and characterization of a murine T-cell lymphoma/leukemia model

    Författare :Ann-Sofie Johansson; Dan Holmberg; Magnus Lindskog; Finn Skou Pedersen; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Mouse model; T-cell lymphoma; Moloney murine leukemia virus; proviral integration; lymphomagenesis; COX-2; omega 3; Oncology; Onkologi; onkologi; Oncology;

    Sammanfattning : Mouse models of human disease are valuable tools for studying pathogenesis and for evaluating novel therapies. T-cell lymphoma is a relatively rare disease in humans, affecting 100-150 persons yearly in Sweden. It exists in both aggressive and more indolent forms. LÄS MER

  5. 34. Affinity protein based inhibition of cancer related signaling pathways

    Författare :Erik Vernet; Torbjörn Gräslund; Antonino Cattaneo; KTH; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Affibody; cancer; endoplasmic reticulum retention; EGFR; HER2; IGF-1R; Raf; Ras; Bioengineering; Bioteknik;

    Sammanfattning : Dysregulation of protein activity, caused by alterations in protein sequence, expression, or localization, is associated with numerous diseases. In order to control the activity of harmful protein entities, affinity ligands such as proteins, oligonucleotides or small molecules can be engineered to specifically interact with them to modulate their function. LÄS MER

  7. 35. Towards ribozyme-mediated gene therapy of HIV-1 infections

    Författare :Graham Hotchkiss; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Ribozymes; HIV-1; Telomere length; HAART; Gene Therapy;

    Sammanfattning : HIV-1 is the causative agent in AIDS, the world's fourth most frequent cause of death. HIV is a retrovirus that primarily infects macrophages and T helper cells - required for a proper immune response. LÄS MER