Sökning: "Moloney murine leukemia virus"

Hittade 5 avhandlingar innehållade orden Moloney murine leukemia virus.

  1. 1. Establishment and characterization of a murine T-cell lymphoma/leukemia model

    Författare :Ann-Sofie Johansson; Dan Holmberg; Magnus Lindskog; Finn Skou Pedersen; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Mouse model; T-cell lymphoma; Moloney murine leukemia virus; proviral integration; lymphomagenesis; COX-2; omega 3; Oncology; Onkologi; onkologi; Oncology;

    Sammanfattning : Mouse models of human disease are valuable tools for studying pathogenesis and for evaluating novel therapies. T-cell lymphoma is a relatively rare disease in humans, affecting 100-150 persons yearly in Sweden. It exists in both aggressive and more indolent forms. LÄS MER

  3. 2. Semliki forest virus-derived packaging system for production of retroviral vectors

    Författare :Ke-Jun Li; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Moloney murine leukemia virus; Semliki Forest virus; gene therapy; retroviral vector; intron; human bone marrow stromal cell;

    Sammanfattning : Gene therapy is a treatment of disease by transfer of genetic material into somatic cells of an individual. Successful gene therapy depends on a delivery system which can efficiently transfer the gene into target cells and lead to high level expression of the gene. LÄS MER

  4. 3. Activation of retrovirus spikes for membrane fusion

    Författare :Robin Löving; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Retroviruses are enveloped viruses that use reverse transcriptase to convert their RNA genome into DNA which is integrated into the host DNA. They enter into the cell by a membrane fusion process. In this the viral membrane fuses with that of the cell so that the internal capsid of the virus with the genome can be released into the cell cytoplasm. LÄS MER

  5. 4. Screening for Candidate Brain Tumor Genes : Identifying Genes that Cooperate with Platelet-Derived Growth Factor in Glioma Development and Progression

    Författare :Fredrik Johansson; Bengt Westermark; Leif Carlsson; Uppsala universitet; []
    Nyckelord :Pathology; PDGF; insertional mutagenesis; retroviral tagging; common insertion site; glioma; expression; cGMP-dependent protein kinase II; Patologi;

    Sammanfattning : Malignant primary brain tumors, gliomas, often overexpress both platelet-derived growth factor (PDGF) ligands and receptors providing an autocrine and/or paracrine boost to tumor growth. Glioblastoma multiforme (GBM) is the most frequent glioma. Its aggressive and infiltrative growth renders it extremely difficult to treat. LÄS MER

  7. 5. Reverse Transcriptase Activity Assays for Retrovirus Quantitation and Characterization

    Författare :Anders Malmsten; Ulf Gyllensten; Clas Källander; Lynn Morris; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicine; retrovirus; reverse transcriptase; enzyme activity assay; MuLV; HIV; RT purification; viral load; drug susceptibility; Medicin; Dermatology and venerology; clinical genetics; internal medicine; Dermatologi och venerologi; klinisk genetik; invärtesmedicin;

    Sammanfattning : Reverse transcriptase (RT) is a crucial enzyme for retrovirus replication, and its presence in the virion is indispensable for infectivity. This thesis illustrates the use of RT activity assays as tools for quantitation and characterization of different retroviruses, particularly HIV. LÄS MER