Sökning: "T-cell lymphoma"
Visar resultat 1 - 5 av 61 avhandlingar innehållade orden T-cell lymphoma.
1. Epidemiological and clinical aspects of T-cell lymphoma
Sammanfattning : T-cell lymphoma (TCL) is a rare group of malignancies and one of the important aims in this thesis has been to broaden the general knowledge of TCL with descriptive patient data. Main focus has been to examine prognosticfactors for overall survival (OS) and progression-free survival (PFS), and to evaluate different treatment approaches and follow-up (FU) after treatment. LÄS MER
2. Clinical factors and outcome in T-cell lymphoma: a population-based perspective
Sammanfattning : The heterogeneous group of T-cell lymphomas consist mostly of aggressive diseasess, with generally unfavourable outcome compared to aggressive B-cell lymphomas following similar therapy. This thesis focus on outcome and risk factors for inferior survival, in an unselected population-based cohort of T-cell lymphoma patients. LÄS MER
3. Notch signalling in carcinogenesis : With special emphasis on T-cell lymphoma and colorectal cancer
Sammanfattning : The Notch signalling pathway is an evolutionary conserved pathway, named after the Notch receptors, Notch1-4 in mammals, which upon cell-cell contact and ligand binding releases the intracellular domain (NICD). NICD translocates into the nucleus where it binds the transcriptional repressor RBP-Jk, which together with co-activators belonging to the Mastermind-like family of proteins form a transcriptional activation complex. LÄS MER
4. Establishment and characterization of a murine T-cell lymphoma/leukemia model
Sammanfattning : Mouse models of human disease are valuable tools for studying pathogenesis and for evaluating novel therapies. T-cell lymphoma is a relatively rare disease in humans, affecting 100-150 persons yearly in Sweden. It exists in both aggressive and more indolent forms. LÄS MER
5. Investigating histidine-rich glycoprotein and T cell-specific adaptor as potential biomarkers and therapeutic targets
Sammanfattning : The endothelial cell (EC), the most important cell type in blood vessels, lines the vessel wall and provides vessel integrity. EC function is tightly regulated, and its dysregulation is a key element in many diseases including cardiovascular disease, cancer and several diseases of the eye. LÄS MER