Sökning: "IGF-1R"

Visar resultat 1 - 5 av 42 avhandlingar innehållade ordet IGF-1R.

  1. 1. Molecular function and targeting of β-arrestins in cancer

    Detta är en avhandling från Stockholm : Karolinska Institutet, Dept of Oncology-Pathology

    Författare :Huiyuan Zheng; Karolinska Institutet.; Karolinska Institutet.; [2012]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; IGF-1R;

    Sammanfattning : In the selection leading to cancer, cancer cells make use of the normal extracellular signaling to gain a growth advantage over normal cells. These signals are, in part, generated by plasma membrane receptors. G Protein Coupled Receptors (GPCRs) and Receptor Tyrosine Kinases (RTKs) are major transducer of signals across the plasma membrane. LÄS MER

  2. 2. IGF-1R : Studies on the expression and role in transformation

    Detta är en avhandling från Stockholm : Karolinska Institutet, Department of Oncology-Pathology

    Författare :Natalia Natalishvili; Karolinska Institutet.; Karolinska Institutet.; [2009]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Transformation is a complex nonlinear multistep process during which normal cell becomes cancerous. Main characteristics of transformed cells include uncontrolled growth, invasion and metastasis. LÄS MER

  3. 3. Engineering of Affibody molecules for Radionuclide Molecular Imaging and Intracellular Targeting

    Detta är en avhandling från Stockholm : KTH Royal Institute of Technology

    Författare :Camilla Hofström; KTH.; [2013]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Affibody molecules; affinity proteins; radionuclide molecular imaging; intracellular targeting; EGFR; HER2; IGF-1R; SRA - Molekylär biovetenskap; SRA - Molecular Bioscience;

    Sammanfattning : Affibody molecules are small (7 kDa) affinity proteins of non-immunoglobulin origin that have been generated to specifically interact with a large number of clinically important molecular targets.In this thesis, Affibody molecules have been employed as tracers for radionuclide molecular imaging of HER2- and IGF-1R-expressing tumors, paper I-IV, and for surface knock-down of EGFR, paper V. LÄS MER

  4. 4. Affinity protein based inhibition of cancer related signaling pathways

    Detta är en avhandling från Stockholm : KTH

    Författare :Erik Vernet; KTH.; [2009]
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Affibody; cancer; endoplasmic reticulum retention; EGFR; HER2; IGF-1R; Raf; Ras; TECHNOLOGY Bioengineering; TEKNIKVETENSKAP Bioteknik;

    Sammanfattning : Dysregulation of protein activity, caused by alterations in protein sequence, expression, or localization, is associated with numerous diseases. In order to control the activity of harmful protein entities, affinity ligands such as proteins, oligonucleotides or small molecules can be engineered to specifically interact with them to modulate their function. LÄS MER

  5. 5. SUMO and ubiquitin : The Yin and Yang of IGF-1R function

    Detta är en avhandling från Stockholm : Karolinska Institutet, Department of Oncology-Pathology

    Författare :Bita Sehat; Karolinska Institutet.; Karolinska Institutet.; [2007]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Tumorigenesis is a multistep process involving genetic and epigenetic alterations that drive the progressive transformation of normal human cells into highly malignant derivatives. The insulin-like growth factor 1 receptor (IGF-1R) plays pivotal roles in cancer. LÄS MER