Sökning: "Affibody"
Visar resultat 1 - 5 av 89 avhandlingar innehållade ordet Affibody.
1. Targeting Human Epidermal Growth Factor Receptors with Drug Conjugates Based on Affibody Molecules
Sammanfattning : Cancer is a major public health challenge and the second leading cause of death in the world, with millions of new cases being diagnosed each year. Traditional cancer treatments such as surgery, radiation therapy, and chemotherapy are many times effective, but may also cause damage to healthy cells, leading to side effects. LÄS MER
2. Affibody molecules for proteomic and therapeutic applications
Sammanfattning : This thesis describes generation and characterization of Affibody molecules with future applications in proteomics research, protein structure determinations, therapeutic treatment of disease and medical imaging for in vivo diagnostics. Affibody molecules are engineered affinity proteins developed by combinatorial protein engineering from the 58-residue protein A-derived Z domain scaffold. LÄS MER
3. Cellular Studies of HER-family Specific Affibody Molecules
Sammanfattning : The human epidermal growth-factor like receptor (HER) family of receptor tyrosine kinases are important targets for cancer therapy. The family consists of four members - EGFR, HER2, HER3 and HER4 - that normally transfer stimulatory signals from extracellular growth factors to the intracellular signalling network. LÄS MER
4. Radiolabeled HER-2 Binding Affibody Molecules for Tumor Targeting : Preclinical Studies
Sammanfattning : Conventional cancer treatment based on radiotherapy or chemotherapy affects all dividing cells. By directing the therapy specifically to the tumor cells, normal cells can be spared. Tumor targeting molecules carrying a cytotoxic moiety is then an attractive approach. LÄS MER
5. Ribosome display for selection and evolution of affibody molecules
Sammanfattning : Affinity proteins are invaluable tools in biotechnological and medical applications. This thesis is about combinatorial protein engineering principles for the generation of novel affinity proteins to purify mouse immunoglobulin, detect a potential cancer marker protein or inhibit a cell proliferation pathway. LÄS MER