Sökning: "PKC"

Visar resultat 6 - 10 av 138 avhandlingar innehållade ordet PKC.

  1. 6. Ischemic Tolerance and Cell Signaling in the Rat Brain

    Författare :Mehrdad Shamloo; Lund Wallenberg Neurocentrum; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; preconditioning; cell death; tyrosine phosphorylation; tolerance; ERK; Calpain; CaMKII; PKC; protection; Brain; ischemia; Neurology; neuropsychology; neurophysiology; Neurologi; neuropsykologi; neurofysiologi;

    Sammanfattning : A brief period of sublethal ischemia in the brain induces resistance to a subsequent, otherwise lethal ischemic insult. This phenomenon is known as ischemic tolerance or preconditioning. A model of ischemic preconditioning in the rat brain using the two-vessel occlusion model of global cerebral ischemia was established. LÄS MER

  3. 7. Caspase activation in human neuroblastoma cells: mechanisms and spatiotemporal aspects

    Författare :Elena V. Ivanova; Kerstin Iverfeldt; Boris Zhivotovsky; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; apoptosis; caspase; local caspase activation; neurodegeneration; tau-anchored FRET sensors; tAFS; cancer; neuroblastoma; TNF-related apoptosis inducing ligand; TRAIL; protein kinase C; PKC; X-linked inhibitor of apoptosis protein; XIAP; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

    Sammanfattning : Apoptosis is one of the modes of programmed cell death, in which several members of the caspase family of proteases play the central role. However, activation of apoptotic caspases does not necessarily lead to cell death. LÄS MER

  4. 8. Experimental vitreoretinal surgery in the rabbit eye - electrophysiology and morphology

    Författare :Karin Gjörloff; Lund Oftalmologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oftalmologi; Ophtalmology; retinectomy; GFAP; PKC; rabbit; vitrectomy; focal laser photocoagulation; full-field electroretinography; multifocal electroretinography;

    Sammanfattning : The field of vitreoretinal surgery has expanded greatly over the last decades. A continuous refinement of surgical methods and instruments has increased the number of treatable retinal disorders. Vitrectomy, retinectomy and laser treatment are all part of the modern surgical arsenal. LÄS MER

  5. 9. Regulation of glucagon secretion from pancreatic alpha cells

    Författare :Yang De Marinis; diabetes och endokrinologi Genomik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Epac2; glucagon secretion; pancreatic alpha cells; K- ATP channel; N-type Ca2 channel; L-type Ca2 channel; GLP-1; cAMP; PKA; Adrenaline; PKC;

    Sammanfattning : Glucagon secreted by pancreatic α-cells plays an important role in the regulation of blood glucose. In this thesis, different techniques such as electrophysiology, immunohistochemistry and hormone secretion assay were combined to explore the mechanisms by which glucagon secretion is regulated. LÄS MER

  7. 10. Alcohol and gene expression in nerve cells with emphasis on transcription factor AP-1

    Författare :Ulrik Fried; Institutionen för laboratoriemedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; nerve cells; SH-SY5Y; muscarinic receptors; MAPKs; PKC; gene expression; jun; Activating Protein-1; Alcohol; ethanol; CRABP-I; Clinical chemistry; Klinisk kemi;

    Sammanfattning : Alcohol induces profound effects on the function of the nerve cells in the nervous system. Alterations in gene expression is an important way by which these effects could be induced and sustained. Activating Protein-1 (AP-1) is a dimeric transcription factor constituted of proteins from the fos and jun immediate-early gene families. LÄS MER