Sökning: "Y-1"

Visar resultat 1 - 5 av 19 avhandlingar innehållade ordet Y-1.

  1. 1. In Vitro Studies of Adrenocorticolytic DDT Metabolites, with Special Focus on 3-methylsulfonyl-DDE

    Författare :Vendela Asp; Ingvar Brandt; Ulrika Bergström; Olle Söder; Uppsala universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Toxicity; 3-methylsulfonyl-DDE; CYP; adrenal cortex; metabolic activation; steroid hormones; Y-1; H295R; mitotane; adrenocortical carcinoma; Toxicology; Toxikologi; Biologi med inriktning mot ekotoxikologi; Biology with specialization in Environmental Toxicology;

    Sammanfattning : The DDT metabolite 3-methylsulfonyl-DDE (3-MeSO2-DDE) is bioactivated by cytochrome P450 11B1 (CYP11B1) in the adrenal cortex of mice and forms irreversibly bound protein adducts, reduces glucocorticoid secretion, and induces cell death selectively in cortisol-producing adrenocortical cells. 3-MeSO2-DDE has therefore been proposed as a lead compound for an improved adrenocortical carcinoma (ACC) therapy. LÄS MER

  2. 2. Adrenocorticolysis Induced by 3-MeSO2-DDE : Mechanisms of Action, Kinetics and Species Differences

    Författare :Veronica Lindström; Ingvar Brandt; Ulrika Bergström; Eva Brittebo; Hans Tjälve; Uppsala universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; Toxicology; 3-methylsulphonyl-DDE; o; p -DDD; CYP11B1; adrenal cortex; tissue-specific toxicity; bioactivation; kinetics; Y-1 cells; Toxikologi; Biology; Biologi;

    Sammanfattning : The DDT metabolite 3-methylsulphonyl-DDE (3-MeSO2-DDE) induces cell death specifically in the adrenal cortex of mice after a cytochrome P45011B1 (CYP11B1)-catalysed bioactivation. This substance is not only an environmental pollutant, but also a suggested lead compound for an improved chemotherapy of adrenocortical carcinoma (ACC). LÄS MER

  3. 3. Land-atmosphere interaction of a subarctic palsa mire

    Författare :Marcin Jackowicz-Korczynski; Institutionen för naturgeografi och ekosystemvetenskap; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; eddy covariance; chamber; methnaol; isoprene; nonmethane hydrocarbons; methane; carbon dioxide; carbon; mire; permafrost; subarctic; palsa; greenhouse gas;

    Sammanfattning : The main objective of this thesis was to quantitatively estimate the gaseous exchange of carbon dioxide (CO2) and methane (CH4) between a subarctic wetland ecosystem and the atmosphere. Additionally some initial estimates of the carbon input to the atmosphere of nonmethane hydrocarbons (NMHCs) were also obtained by combining different techniques in a joint setting. LÄS MER

  4. 4. Radiation exposure of human populations in villages in Russia and Belarus affected by fallout from the Chernobyl reactor

    Författare :Christian Bernhardsson; Malmö Medicinsk strålningsfysik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Chernobyl; caesium; effective dose; OSL; NaCl; TL; LiF; radiation protection survey instruments; deposition variability; long-term series;

    Sammanfattning : A quarter of a century has elapsed since the catastrophe at the nuclear power plant in Chernobyl. The radioactive fallout affected all the European countries and most severely the three countries of Belarus, Russia and Ukraine. LÄS MER

  5. 5. Ectomycorrhizal fungi: Their role in nitrogen retention and carbon sequestration in northern coniferous forests

    Författare :Adam Bahr; MEMEG; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Ectomycorrhizal fungi; Carbon sequestration; Nitrogen deposition; Nitrogen leakage; Field survey; Boreo-nemoral forest; Boreal Forest; Ergosterol; Free ergosterol; Mesh-bags; Multivariate analysis;

    Sammanfattning : Almost all northern forest tree species live in symbioses with ectomycorrhizal fungi (EMF). The trees allocate up to half of the photoassimilated carbon (C) through the roots to EMF. In return EMF deliver nutrients from both inorganic and organic sources in the soil, as well as water. LÄS MER