Sökning: "Metabolic activation"

Visar resultat 16 - 20 av 246 avhandlingar innehållade orden Metabolic activation.

  1. 16. Energy flow and metabolic efficiency attributed to brown adipose tissue

    Författare :Gabriella von Essen; Jan Nedergaard; Susanne Klaus; Stockholms universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Brown adipose tissue; BAT; UCP1; diet-induced thermogenesis; DIT; obesity; high-fat diet; energy expenditure; Physiology; fysiologi;

    Sammanfattning : The large capacity of brown adipose tissue (BAT) to expend energy as heat makes it an interesting potential player in weight regulation and other metabolic conditions. This is of particular interest as it has been recognized that adult humans possess BAT. LÄS MER

  2. 17. Estrogen signaling in metabolic disease : a functional genomics approach

    Författare :Hui Gao; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; estrogen receptor; insulin sensitivity; functional genomics; mouse liver; lipid metabolism;

    Sammanfattning : Estrogens have traditionally been associated with female reproduction. More and more evidence has also linked estrogens to maintenance of glucose homeostasis and normal heart function. LÄS MER

  3. 18. Mutational Analysis and Redesign of Alpha-class Glutathione Transferases for Enhanced Azathioprine Activity

    Författare :Olof Modén; Bengt Mannervik; Mikael Widersten; Kenneth Tew; Uppsala universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; NATURVETENSKAP; TEKNIK OCH TEKNOLOGIER; NATURAL SCIENCES; ENGINEERING AND TECHNOLOGY; allelic variants; azathioprine; bioactivation; chimeric mutagenesis; directed evolution; DNA shuffling; enzyme engineering; glutathione transferase; GST; lysate screening; molecular docking; multiple alignment; multivariate analysis; polymorphism; principal component analysis; prodrug; prodrug activation; protein engineering; protein redesign; reduced amino acid alphabet; saturation mutagenesis; semi-rational enzyme engineering; site-directed mutagenesis; structure-activity relationship; structure-based redesign; Biokemi; Biochemistry;

    Sammanfattning : Glutathione transferase (GST) A2-2 is the human enzyme most efficient in catalyzing azathioprine activation. Structure-function relationships were sought explaining the higher catalytic efficiency compared to other alpha class GSTs. LÄS MER

  4. 19. Novel aspects of metabolic regulation and inflammation in human adipocytes

    Författare :Annie Pettersson; Karolinska Institutet; Karolinska Institutet; []

    Sammanfattning : The significance of adipose tissue and obesity has been recognized in numerous pathologies. However, the mechanisms behind this connection are not yet completely understood. LÄS MER

  5. 20. Evaluation of precursor and cofactor engineering strategies influencing fatty acid metabolism in Saccharomyces cerevisiae

    Författare :Alexandra Linda Bergman; Chalmers University of Technology; []
    Nyckelord :NATURVETENSKAP; TEKNIK OCH TEKNOLOGIER; TEKNIK OCH TEKNOLOGIER; NATURAL SCIENCES; ENGINEERING AND TECHNOLOGY; ENGINEERING AND TECHNOLOGY; Saccharomyces cerevisiae; metabolic engineering; fatty acids; oleochemicals; NADPH; Sustainability; phosphoketolase; acetyl-CoA; transcription factor;

    Sammanfattning : If humanity is to reduce the rate of climate change, it is essential that our societies switch to a more sustainable production of fuels and chemicals, which in turn depends on technological development. Oleochemical production via microbial catalysts – such as the yeast Saccharomyces cerevisiae – can use a considerably broader range of renewable substrates compared to the conventional production processes. LÄS MER