Sökning: "H295R"

Hittade 4 avhandlingar innehållade ordet H295R.

  1. 1. In Vitro Studies of Adrenocorticolytic DDT Metabolites, with Special Focus on 3-methylsulfonyl-DDE

    Författare :Vendela Asp; Ingvar Brandt; Ulrika Bergström; Olle Söder; Uppsala universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Toxicity; 3-methylsulfonyl-DDE; CYP; adrenal cortex; metabolic activation; steroid hormones; Y-1; H295R; mitotane; adrenocortical carcinoma; Toxicology; Toxikologi; Biologi med inriktning mot ekotoxikologi; Biology with specialization in Environmental Toxicology;

    Sammanfattning : The DDT metabolite 3-methylsulfonyl-DDE (3-MeSO2-DDE) is bioactivated by cytochrome P450 11B1 (CYP11B1) in the adrenal cortex of mice and forms irreversibly bound protein adducts, reduces glucocorticoid secretion, and induces cell death selectively in cortisol-producing adrenocortical cells. 3-MeSO2-DDE has therefore been proposed as a lead compound for an improved adrenocortical carcinoma (ACC) therapy. LÄS MER

  2. 2. Steroidogenesis studied in a human adrenocortical cell line : effects of single chemicals and mixtures

    Författare :Åsa Ohlsson; Sveriges lantbruksuniversitet; Sveriges lantbruksuniversitet; []
    Nyckelord :LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES;

    Sammanfattning : Steroidogenesis may be a target for endocrine disrupting chemicals; unfortunately data of such effects is limited. The aim of this thesis was to study effects on steroidogenesis of single chemicals and mixtures in the human adrenocarcinoma cell line H295R. Screening for effects on steroid secretion was performed by ELISA. LÄS MER

  3. 3. Interaction of Xenobiotics with the Glucocorticoid Hormone System in vitro

    Författare :Maria Johansson; Helen Håkansson; Uppsala universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; Biology; DDT; PCB; tolylfluanid; adrenal; CYP11B1; glucocorticoid receptor; endocrine disrupter; Biologi; Biology; Biologi; Ecotoxicology; ekotoxikologi;

    Sammanfattning : Persistent environmental pollutants were examined for their interaction with the glucocorticoid hormone system. The focus was placed on interference with the glucocorticoid synthesis and the glucocorticoid-signalling pathway in various in vitro test systems. LÄS MER

  4. 4. Adrenocorticolysis Induced by 3-MeSO2-DDE : Mechanisms of Action, Kinetics and Species Differences

    Författare :Veronica Lindström; Ingvar Brandt; Ulrika Bergström; Eva Brittebo; Hans Tjälve; Uppsala universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; Toxicology; 3-methylsulphonyl-DDE; o; p -DDD; CYP11B1; adrenal cortex; tissue-specific toxicity; bioactivation; kinetics; Y-1 cells; Toxikologi; Biology; Biologi;

    Sammanfattning : The DDT metabolite 3-methylsulphonyl-DDE (3-MeSO2-DDE) induces cell death specifically in the adrenal cortex of mice after a cytochrome P45011B1 (CYP11B1)-catalysed bioactivation. This substance is not only an environmental pollutant, but also a suggested lead compound for an improved chemotherapy of adrenocortical carcinoma (ACC). LÄS MER