Sökning: "Reactive Metabolite"

Visar resultat 1 - 5 av 26 avhandlingar innehållade orden Reactive Metabolite.

  1. 1. Electrochemical and Enzymatic In Vitro Studies on Reactive Drug Metabolites. Synthesis, Characterization and Avoidance

    Författare :Tove Johansson Mali´n; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Nyckelord :Cytochrome P450; Drug; Electrochemical oxidation; Electrochemistry; Intermediate; Metabolism; Metabolic activation; Mimicry; Reactive Metabolite; Trapping.;

    Sammanfattning : During development of pharmaceuticals, it is essential to as early as possible identify and preferably avoid formation of reactive metabolites and intermediates. Reactive metabolites may represent obstacles in the development and use of drugs, due to their potential toxicity. LÄS MER

  2. 2. Drug Metabolites Formed by Cunninghamella Fungi : Mass Spectrometric Characterization and Production for use in Doping Control

    Författare :Axel Rydevik; Mikael Hedeland; Ulf Bondesson; David Cowan; Uppsala universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cunninghamella blakesleeana; Cunninghamella elegans; Doping Control; Drug Metabolites; Glucuronide Production; Mass Spectrometry; Reactive Metabolites; Reference Material; Structural Characterization; Analytical Pharmaceutical Chemistry; Analytisk farmaceutisk kemi;

    Sammanfattning : This thesis describes the in vitro production of drug metabolites using fungi of the Cunninghamella species. The metabolites were characterized with mainly liquid chromatography-mass spectrometry using ion-trap and quadrupole-time-of-flight instruments. A fungal in vitro model has several advantages e.g. LÄS MER

  3. 3. Environmental risk factors for multiple sclerosis

    Författare :Jonatan Salzer; Peter Sundström; Kjell-Morten Myhr; Umeå universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Multiple sclerosis; risk factors in epidemiology; prospective; month of birth; vitamin D; vitamin A; C-reactive protein; hygiene hypothesis; smoking; cotinine; Epstein-Barr virus; Epidemiology; epidemiologi;

    Sammanfattning : Background Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system. It usually strikes during young adulthood, and 2.5 million individuals are estimated to have the disease worldwide. LÄS MER

  4. 4. Characterization of toxicological effects of a novel in vivo benzo[a]pyrene metabolite in colonic cells

    Författare :Mirjam Nordling; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; Polycyclic aromatic hydrocarbons; benzo[a]pyrene; colon cancer; genotoxicity; oxidative DNA damage.;

    Sammanfattning : Cancer of the colon and rectum is the third most common cancer form in the world. Where the majority of cases fall into the category of sporadic colorectal cancer (CRC), lifestyle and diet have been found to be important risk factors associated with CRC. LÄS MER

  5. 5. In vivo dosimetry of some important industrial chemicals by measurement of their reaction products with hemoglobin

    Författare :Hermes Licea Pérez; Åke Bergman; Stockholms universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; Physical Biology; fysikalisk biologi;

    Sammanfattning : Hemoglobin adduct measurements provide a useful tool for the development of models for risk assessment of chemicals. The measurements can be used to identify reactive metabolites and to determine the in vivo doses of these metabolites. LÄS MER