Sökning: "HSA"

Visar resultat 16 - 20 av 41 avhandlingar innehållade ordet HSA.

1. 16. Protein Modifications by Low Molecular Weight Chemicals Inducing Airways Diseases

   Författare :Marina Jeppsson; Avdelningen för arbets- och miljömedicin; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MSight; hemoglobin human serum albumin; nasal lavage; acrylates; organic acid anhydrides; persulfate; biomarkers adducts; mass spectrometry; MoDetect;

   Sammanfattning : Airways diseases are one of the most common health effects in the western world today. It has been shown that low molecular weight chemicals (LMWC) can cause airways diseases. The mechanisms for these diseases are not well known in most cases. Also, methods for biological monitoring of exposure are not available for many of these LMWC. LÄS MER

3. 17. Bifunctional ADAPTs: Opportunity for serological Half-life extension and Targeted therapy

   Författare :Andreas Wisniewski; Sophia Hober; Masood Kamali-Moghaddam; KTH; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ABD; ADAPT; Autoimmune diseases; Cancer; Half-life extension; HRP; Phage Display; Protein Engineering; Targeted therapy; Biotechnology; Bioteknologi;

   Sammanfattning : Small engineered scaffold proteins (ESPs) gain more and more popularity as biological drugs, due to their specificity and applicability in diagnostics and therapy. Thanks to their high stability, low immunogenicity and low production cost, they present themselves as a promising alternative to the market-leading antibodies. LÄS MER

4. 18. miRNA and Asymmetric siRNA : Small RNAs with Large Effects on Bone Metabolism

   Författare :Navya Laxman; Andreas Kindmark; Sara Windahl; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; miRNA; cp-siRNA; RNAi; bone; Osteoblast; Sequencing; Differential expression; Wnt pathway; Biology with specialization in Molecular Biology; Biologi med inriktning mot molekylärbiologi;

   Sammanfattning : RNA interference (RNAi) is a post-transcriptional gene silencing process elicited by double-stranded RNA, such as micro-RNA (miRNA) and small interfering RNA (siRNA). They are 18-25 nucleotide long, small non-coding RNAs acting as critical regulators in eukaryotic genome expression. LÄS MER

5. 19. Evaluation of prostheses in shoulder arthroplasty : methods for assessment of outcome

   Författare :Magnus Ödquist; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Today, the shoulder joint is the third most commonly replaced joint after the hip and knee joints and the incidence is increasing. In Sweden, 1863 primary Shoulder Arthroplasties and 195 revisions were performed in 2017. LÄS MER

7. 20. Bioinformatics tools for discovery and evaluation of biomarkers : Applications in clinical assessment of cancer

   Författare :Benjamin Ulfenborg; Björn Olsson; Karin Klinga-Levan; Erik Larsson Lekholm; Högskolan i Skövde; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Algorithms; biomarkers; machine learning; classification; cancer; microRNA database; microRNA discovery; partial least squares; Medical sciences; Medicin; Bioinformatik; Bioinformatics; Biomedicin;

   Sammanfattning : Cancer is a disease characterized by abnormal proliferation of cells in the body and ranks as the second leading cause of death worldwide. In order to improve cancer patient care, a major focus of cancer research is to discover biomarkers. LÄS MER