Sökning: "Osteoblast"

Visar resultat 1 - 5 av 56 avhandlingar innehållade ordet Osteoblast.

  1. 1. CD47–SIRPα : an interaction of importance for bone cell differentiation

    Författare :Cecilia Koskinen; Pernilla Lundberg; Per-Arne Oldenborg; Riku Kiviranta; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CD47; SIRPalpha; osteoblast; osteoclast; SHP-2; Akt2; cell research; cellforskning;

    Sammanfattning : Bone tissue is continuously remodeled by bone-forming osteoblasts and bone-resorbing osteoclasts, in processes tightly regulated by hormones, cytokines and growth factors. CD47, a ubiquitously expressed protein, and one of its ligands, signal-regulatory protein alpha (SIRPα), are two cell-surface proteins belonging to the immunoglobulin (Ig)-superfamily. LÄS MER

  3. 2. Insulin-coated titanium implants - a potential therapy for local bone regeneration

    Författare :Behnosh Öhrnell Malekzadeh; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Insulin; Titanium; Bone; Implant; Osteoblast; Immobilisation;

    Sammanfattning : Background: Insulin is a hormone that regulates glucose metabolism, however, it is also important for bone formation. The anabolic effect of insulin on bone could open up alternative therapies when it comes to local bone regeneration. However, this requires a method for local administration of insulin. LÄS MER

  4. 3. Nano-porous Alumina, a Potential Bone Implant Coating

    Författare :Marjam Karlsson; Karin Caldwell; Mats Boman; Matteo Santin; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Chemistry; Nano-porous aluminium oxide; Biomaterial; Hard tissue implant; Surface topography; Osteoblast; Biocompatibility; Neutrophil; Inflammation; Kemi; Chemistry; Kemi;

    Sammanfattning : This thesis describes a method of growing a highly adherent nano-porous alumina coating on titanium implant materials, a design which might be useful in hard tissue replacement. Alumina layers were formed by anodisation of aluminium, which had been deposited on titanium and titanium alloys by electron beam evaporation. LÄS MER

  5. 4. miRNA and Asymmetric siRNA : Small RNAs with Large Effects on Bone Metabolism

    Författare :Navya Laxman; Andreas Kindmark; Sara Windahl; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; miRNA; cp-siRNA; RNAi; bone; Osteoblast; Sequencing; Differential expression; Wnt pathway; Biology with specialization in Molecular Biology; Biologi med inriktning mot molekylärbiologi;

    Sammanfattning : RNA interference (RNAi) is a post-transcriptional gene silencing process elicited by double-stranded RNA, such as micro-RNA (miRNA) and small interfering RNA (siRNA). They are 18-25 nucleotide long, small non-coding RNAs acting as critical regulators in eukaryotic genome expression. LÄS MER

  7. 5. The neuropeptide VIP and the IL-6 family of cytokines in bone : effects on bone resorption, cytokine expression and receptor signalling in osteoblasts and bone marrow stromal cells

    Författare :Emma Persson; Ulf Lerner; Andreas Kindmark; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; osteoblast; bone resorption; cytokines; IL-6; neuropeptides; VIP; transcription factor; Cell biology; Cellbiologi;

    Sammanfattning : Bone tissue is continuously degraded and rebuilt to respond to the needs of the body. Cells of the osteoblast lineage are responsible for the formation of bone, whereas the resorption of bone tissue is carried out by osteoclasts. LÄS MER