Sökning: "Autoimmune diseases"

Visar resultat 1 - 5 av 392 avhandlingar innehållade orden Autoimmune diseases.

  1. 1. Strategies for Identification of Susceptibility Genes in Complex Autoimmune Diseases

    Författare :Ludmila Prokunina; Marta Alarcon-Riquelme; Ulf Gyllensten; Juha Kere; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; complex diseases; autoimmune diseases; genetic mapping; functional studies; Genetik; Clinical genetics; Klinisk genetik;

    Sammanfattning : Systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) are complex autoimmune diseases affecting 0.05-2% of the population worldwide. Genetic studies detected linkage with SLE in the 2q37 region, and intensive family-based and case-control association studies in several populations identified that allele A of the SNP PD-1. LÄS MER

  3. 2. Implications of Heparan Sulfate and Heparanase in Inflammatory Diseases

    Författare :Andreas Digre; Jin-Ping Li; Lena Kjellén; Liliana Schaefer; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Heparanase; Heparan sulfate; Inflammation; Inflammatory diseases; Autoimmune diseases; Amyloidosis; Reumathoid arthritis; SAA; APP; A beta; Neuroinflammation; Medical Science; Medicinsk vetenskap; Medical Biochemistry; Medicinsk biokemi; Immunologi; Immunology; Neurology; Neurologi;

    Sammanfattning : Heparan sulfate (HS), an unbranched sulfated carbohydrate chain, and the HS-degrading enzyme heparanase play important roles in physiological and pathological processes during all stages of life, from early embryogenesis to ageing. Accumulated information shows that HS and heparanase are involved in inflammatory processes and associated diseases, e. LÄS MER

  4. 3. Transglutaminase and peptidylarginine deiminase in the pathogenesis of autoimmune diseases

    Författare :Bodil Roth; Gastroenterologi; []
    Nyckelord :multiple sclerosis; pathogenesis; peptidylargininedeiminase; transglutaminase.; Sjögren’s syndrome; autoimmune; Alzheimer’s disease;

    Sammanfattning : Coeliac disease (CD) is becoming a model for understanding the pathogenesis of autoimmune disorders. In CD, antibodies against transglutaminase 2 (TG2) and specific glutamine residues of gliadins have been identified. LÄS MER

  5. 4. Autoantibody profiling in autoimmune diseases

    Författare :Shaghayegh Bayati; Peter Nilsson; Elisa Pin; Peter Heeringa; KTH; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Autoimmunity; Autoantibodies; Vasculitis; Systemic Sclerosis; affinity proteomics; Biotechnology; Bioteknologi;

    Sammanfattning : Autoimmune disease diagnosis and definition of prognosis can be challenging. Patients with the same autoimmune disease could present with very heterogeneous symptoms. Therefore, there is a need to understand the disease better to improve patients’ diagnosis, and classification, and tailor the treatment. LÄS MER

  7. 5. Clinical and experimental studies of organ-specific autoimmune diseases : With special reference to Addison's disease and autoimmune hepatitis : by Gennet Gebre-Medhin

    Författare :Gennet Gebre-Medhin; Uppsala universitet; []
    Nyckelord :Medical sciences; Addison s Disease; replacement therapy; DHEA; autoimmune hepatitis; APS I; autoantigen; cytochrome P4501A2; aromatic L-amino acid decarboxylase; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; Medicine; medicin;

    Sammanfattning : Organ-specific autoimmunity constitutes a large health problem, where both the clinical management and our understanding of the pathogenetic mechanisms need to improve. Women with Addison's disease have abnormally low levels of dehydroepiandrosterone (DHEA), its sulphate ester (DHEA-S) and androgens relative to age, and many patients complain of physical and mental fatigue and low stress tolerance. LÄS MER