Sökning: "biomarkers adducts"

Visar resultat 1 - 5 av 20 avhandlingar innehållade orden biomarkers adducts.

  1. 1. Biomarkers of aromatic isocyanates in exposed workers

    Författare :Pernilla Lind; Avdelningen för arbets- och miljömedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; adducts; biomarkers; exposure; occupational; methylenediphenyl diisocyanate; toluene diisocyanate; amines; isocyanates; polyurethane; Gas chromatography; mass spectrometry; Occupational health; industrial medicine; Yrkesmedicin; arbetsmiljömedicin;

    Sammanfattning : The aromatic isocyanates, toluene diisocyanate (TDI) and methylenediphenyl diisocyanate (MDI), are used in the production of polyurethane (PUR) foams, paints, elastomers and glues. The use of isocyanates is increasing, and exposure to isocyanates is the most common cause of occupational asthma. LÄS MER

  3. 2. Protein adducts of hexahydrophthalic anhydride- chemical structures and biomarkers

    Författare :Monica Kåredal; Avdelningen för arbets- och miljömedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; arbetsmiljömedicin; Yrkesmedicin; industrial medicine; Occupational health; nasal lavage; mass spectrometry; biomarker; human serum albumin; hemoglobin; Hexahydrophthalic anhydride; adducts;

    Sammanfattning : Organic acid anhydrides (OAAs) are low molecular weight chemicals used in the industry for manufacturing of plastics such as epoxy resins. Exposure to these chemicals may lead to symptoms from the eyes and the respiratory tract in form of conjunctivitis, rhinitis and asthma. LÄS MER

  4. 3. DNA adductomics: Method development and integration in biological effect monitoring

    Författare :Giulia Martella; Elena Gorokhova; Hitesh V. Motwani; Brita Sundelin; Gunnar Boysen; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; DNA adducts; Nucleic acids; High-resolution mass spectrometry; Data-independent acquisition; Biological effect monitoring; Environmental contaminants; Biomarkers; Amphipods as sentinel species; Environmental Sciences; miljövetenskap;

    Sammanfattning : Environmental omics can provide informative biomarkers for identifying pathologies or physiological responses to environmental change. Nucleic acid adductomics, one of the newest omics techniques, is particularly well suited for assessing exposure and effects of environmental contaminants because the technique can capture modifications at the (epi)genome level. LÄS MER

  5. 4. Biological and air monitoring of exposure to isocyanates

    Författare :Carl Johan Sennbro; Avdelningen för arbets- och miljömedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; industrial medicine; Occupational health; asthma; protein adducts; polyurethane; biomarkers; occupational exposure; DBA; ICA; NDI; MDI; TDI; Diisocyanates; Isocyanates; Biomonitoring; Air monitoring; arbetsmiljömedicin; Yrkesmedicin;

    Sammanfattning : Exposure to isocyanates may induce disorders in the airways of workers. Therefore, application, development and validation of methods for exposure assessment is of great importance. LÄS MER

  7. 5. Biomarkers of internal exposure/dose : Methods to quantify adducts to protein and DNA by LC/MS studied with benzo[a]pyrene and isocyanates

    Författare :Emelie Westberg; Margareta Törnqvist; Kimmo Peltonen; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; biomarker; PAH; serum albumin; adduct; DNA; isocyanate; miljökemi; Environmental Chemistry;

    Sammanfattning : This thesis focuses on methods for quantification by liquid chromatography/mass spectrometry (LC/MS) of specific biomarkers for internal dose of chemicals which induce toxicity through their electrophilic reactivity. In vivo such compounds are short-lived, and could feasibly be measured as their reaction products (adducts) with biomacromolecules. LÄS MER