Sökning: "biomarkers adducts"

Visar resultat 1 - 5 av 18 avhandlingar innehållade orden biomarkers adducts.

  1. 1. Biomarkers of aromatic isocyanates in exposed workers

    Författare :Pernilla Lind; Avdelningen för arbets- och miljömedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; adducts; biomarkers; exposure; occupational; methylenediphenyl diisocyanate; toluene diisocyanate; amines; isocyanates; polyurethane; Gas chromatography; mass spectrometry; Occupational health; industrial medicine; Yrkesmedicin; arbetsmiljömedicin;

    Sammanfattning : The aromatic isocyanates, toluene diisocyanate (TDI) and methylenediphenyl diisocyanate (MDI), are used in the production of polyurethane (PUR) foams, paints, elastomers and glues. The use of isocyanates is increasing, and exposure to isocyanates is the most common cause of occupational asthma. LÄS MER

  2. 2. Protein adducts of hexahydrophthalic anhydride- chemical structures and biomarkers

    Författare :Monica Kåredal; Avdelningen för arbets- och miljömedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; arbetsmiljömedicin; Yrkesmedicin; industrial medicine; Occupational health; nasal lavage; mass spectrometry; biomarker; human serum albumin; hemoglobin; Hexahydrophthalic anhydride; adducts;

    Sammanfattning : Organic acid anhydrides (OAAs) are low molecular weight chemicals used in the industry for manufacturing of plastics such as epoxy resins. Exposure to these chemicals may lead to symptoms from the eyes and the respiratory tract in form of conjunctivitis, rhinitis and asthma. LÄS MER

  3. 3. Biological and air monitoring of exposure to isocyanates

    Författare :Carl Johan Sennbro; Avdelningen för arbets- och miljömedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; industrial medicine; Occupational health; asthma; protein adducts; polyurethane; biomarkers; occupational exposure; DBA; ICA; NDI; MDI; TDI; Diisocyanates; Isocyanates; Biomonitoring; Air monitoring; arbetsmiljömedicin; Yrkesmedicin;

    Sammanfattning : Exposure to isocyanates may induce disorders in the airways of workers. Therefore, application, development and validation of methods for exposure assessment is of great importance. LÄS MER

  4. 4. Biomarkers of internal exposure/dose : Methods to quantify adducts to protein and DNA by LC/MS studied with benzo[a]pyrene and isocyanates

    Författare :Emelie Westberg; Margareta Törnqvist; Kimmo Peltonen; Stockholms universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; biomarker; PAH; serum albumin; adduct; DNA; isocyanate; Environmental Chemistry; miljökemi;

    Sammanfattning : This thesis focuses on methods for quantification by liquid chromatography/mass spectrometry (LC/MS) of specific biomarkers for internal dose of chemicals which induce toxicity through their electrophilic reactivity. In vivo such compounds are short-lived, and could feasibly be measured as their reaction products (adducts) with biomacromolecules. LÄS MER

  5. 5. New approaches for synthesis and analysis of adducts to N-terminal valine in hemoglobin from isocyanates, aldehydes, methyl vinyl ketone and diepoxybutane

    Författare :Ronnie Davies; Margareta Törnqvist; Leif Kronberg; Stockholms universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; carbamoylation; modified-Edman procedure; 5- hydroxymethyl furfural; MISPE; biomarkers; Environmental chemistry; Miljökemi; Environmental Chemistry; miljökemi;

    Sammanfattning : Human exposure to harmful compounds in the environment, from intake via food, occupational exposures or other sources, could have health implications. Exposure to reactive compounds/metabolites can be identified and quantified as hemoglobin (Hb) adducts by mass spectrometry. LÄS MER