Sökning: "Gene Therapy"

Visar resultat 36 - 40 av 697 avhandlingar innehållade orden Gene Therapy.

1. 36. Molecular regulators in cartilage and bone formation

   Författare :Thomas Engstrand; Uppsala universitet; []
   Nyckelord :Medical sciences; cartilage; bone; TGF-beta; BMP; noggin; gene therapy; gene targeting; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; Medicine; medicin;

   Sammanfattning : Cartilage functions as a scaffold for bone formation during development. This process, endochondral ossification, is regulated by systemic hormones and local growth factors. LÄS MER

3. 37. Retargeting of adenovirus vectors. Viral ligands and cellular receptors

   Författare :Petra Henning; Göteborgs universitet; []
   Nyckelord :Adenovirus; vector; gene therapy; gene transfer; retargeting; detargeting; tumor targeting; fiber; pIX; affibody molecule; single chain antibody;

   Sammanfattning : Gene therapy is one of the newest technologies attempted to treat human cancer. Progress in the field has however been hampered by the lack of efficient and safe vectors. Ideal vectors should specifically transduce desired cells in vivo. This thesis is devoted to the development and evaluation of retargeted adenovirus type 5 (Ad5) vectors. LÄS MER

4. 38. Targeted Inhibition of Polycomb Repressive Complexes in Multiple Myeloma : Implications for Biology and Therapy

   Författare :Mohammad Alzrigat; Helena Jernberg-Wiklund; Fredrik Öberg; Kristina Drott; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Multiple Myeloma; Epigenetics; Polycomb; PRC2; PRC1; EZH2; BMI-1; UNC1999; PTC-209; Epigenetic Therapy; Medicinsk vetenskap; Medical Science; Molekylär medicin; Molecular Medicine;

   Sammanfattning : Multiple myeloma (MM) is a hematological malignancy of antibody producing plasmablasts/plasma cells. MM is characterized by extensive genetic and clonal heterogeneity, which have hampered the attempts to identify a common underlying mechanism for disease establishment and development of appropriate treatment regimes. LÄS MER

5. 39. Tumour Survival Signals and Epigenetic Gene Silencing in Multiple Myeloma : Implications for Biology and Therapy

   Författare :Charlotte Fristedt Duvefelt; Helena Jernberg-Wiklund; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Multiple myeloma; Polycomb; apoptosis; cIAP2; IAP-inbibitors; proteasome inhibitors; LBH589; PPP; DZNep;

   Sammanfattning : This thesis is focused on multiple myeloma (MM), a haematological malignancy that still remains incurable. The pathogenesis of MM is not fully understood and there is a large intra-tumour and interclonal genetic variation in MM patients. LÄS MER

7. 40. Effects of ionising and non-ionising radiation in cell systems and a rat model for immuno-therapy

   Författare :Catrin Baureus Koch; Neurokirurgi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Kirurgi; ortopedi; traumatologi; Neurology; traumatology; transplantation; Surgery; orthopaedics; cell cultures; abscopal effect; serologi; Immunologi; serology; Immunology; rat tumour model; radiation therapy; radiation sterilisation; pulsed electric fields; interferon-gamma; immuno-gene therapy; neuropsychology; neurophysiology; Neurologi; neuropsykologi; neurofysiologi; glioblastoma multiforme;

   Sammanfattning : The most malignant brain tumour, glioblastoma multiforme (GBM), has an utterly bad prognosis. In spite of all available therapy, the mean survival time is less than a year. In the unique BRIGTT project (Brain Immuno Gene Tumour Therapy), patients at the Dept of Neurosurgery. LÄS MER