Sökning: "Early-onset"

Visar resultat 16 - 20 av 193 avhandlingar innehållade ordet Early-onset.

1. 16. Search for Type 2 Diabetes Susceptibility Genes Using Multiple Approaches

   Författare :Cecilia Lindgren; Malmö Institutionen för kliniska vetenskaper; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; single nucleotide polymorphism SNP ; transmission-disequilibrium test TDT ; genetic variation; single strand conformational polymorphism SSCP ; gene expression; insulin; glucose; genome-wide scan; linkage; genetic association; Type 2 diabetes; early onset diabetes EOD ; sekretion; diabetologi; Endokrinologi; diabetology; Endocrinology; secreting systems; signal-to-noise ratio SNR ;

   Sammanfattning : Type 2 diabetes mellitus is a multifactorial disorder characterized by chronic hyperglycemia resulting from pancreatic dysfunction and insulin resistance. It is a common disorder with a complex pattern of inheritance, likely to reflect the influence of multiple genetic and environmental factors on the diabetes risk. LÄS MER

3. 17. Genetic studies of children with mental retardation

   Författare :Saideh Rajaei; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Mental retardation; Rett syndrome; RTT; early onset infantile RTT; MECP2; SMR; SNP array; copy number variations; CNV; MECP2 duplication syndrom;

   Sammanfattning : Mental retardation (MR) is characterised by significant limitations in intellectual function and adaptive behaviour. It is estimated that MR affects up to 3% of the population in Europe. Patients with MR are an aetiologically heterogeneous group. Approximately 25-35% of the patients have a genetic diagnosis. LÄS MER

4. 18. Substance use in adolescents and young adults: Interactions of drugs of abuse and the role of parents and peers in early onset of substance use

   Författare :Jonas Berge; Lund Psykiatri; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Substance use; Alcohol; Tobacco; Cannabis; Illicit drugs; Adolescents; Young adults;

   Sammanfattning : Background: Misuse of substances is a major contributor to disability and mortality worldwide. The use of tobacco, alcohol, and illegal drugs in adolescence and young adulthood are well-known risk factors for subsequent substance-related harms. LÄS MER

5. 19. Aggressive antisocial behavior- clinical, cognitive, and behavioral covariates of its persistence

   Författare :Märta Wallinius; Malmö Rättspsykiatri; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; risk assessment; risk factors; externalizing spectrum; mental disorders; persistent criminality; violence; antisocial behavior; prevention;

   Sammanfattning : Introduction Aggressive antisocial behavior is a major challenge to society, and studies on the determinants of its persistence are essential to the development of strategies to prevent violence. Aims & Methods The overall aim of the thesis was to establish covariates of persistent aggressive antisocial behavior in a population-based cohort and in clinically evaluated, prospectively followed, offender groups. LÄS MER

7. 20. Search for MODY and Type 2 diabetes genes

   Författare :Markku Lehto; Malmö Institutionen för kliniska vetenskaper; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Type 2 diabetes; mutation; MODY; mitochondrial DNA; MIDD; insulin deficiency; hepatocyte nuclear factor; Gestational diabetes; glucokinase; Endocrinology; secreting systems; diabetology; Endokrinologi; sekretion; diabetologi;

   Sammanfattning : Diabetes is a heterogeneous disease influenced by both environmental and genetic factors. Maturity-onset diabetes of the young (MODY) is considered as a subform of Type 2 diabetes, which is inherited in an autosomal dominant fashion and expressed at childhood or early adult life. LÄS MER