Sökning: "transmission-disequilibrium test TDT"

Hittade 3 avhandlingar innehållade orden transmission-disequilibrium test TDT.

  1. 1. Search for Type 2 Diabetes Susceptibility Genes Using Multiple Approaches

    Författare :Cecilia Lindgren; Malmö Institutionen för kliniska vetenskaper; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; single nucleotide polymorphism SNP ; transmission-disequilibrium test TDT ; genetic variation; single strand conformational polymorphism SSCP ; gene expression; insulin; glucose; genome-wide scan; linkage; genetic association; Type 2 diabetes; early onset diabetes EOD ; sekretion; diabetologi; Endokrinologi; diabetology; Endocrinology; secreting systems; signal-to-noise ratio SNR ;

    Sammanfattning : Type 2 diabetes mellitus is a multifactorial disorder characterized by chronic hyperglycemia resulting from pancreatic dysfunction and insulin resistance. It is a common disorder with a complex pattern of inheritance, likely to reflect the influence of multiple genetic and environmental factors on the diabetes risk. LÄS MER

  3. 2. Candidate gene analyses and genome-wide screens in multiple sclerosis

    Författare :Vilmantas Giedraitis; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Specific disease causing mutations have been identified for many disorders. Most of these disorders are of Mendelian origin and there have been very few successful attempts in the genetic dissection of complex traits. LÄS MER

  4. 3. Epidemiological and genetic studies of muliple sclerosis with focus on the Swedish county of Värmland

    Författare :Margarita Callander; Anders Svenningsson; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Inborn genetic diseases; Genetic predisposition to disease; Genetic predisposition to disease; Cluster analysis; Muliple sclerosis; Pedigree; Medical genetics; Medicinsk genetik;

    Sammanfattning : The aim of this study was to perform detailed investigations of a presumed high-risk area, namely the county of Värmland, to see if previous results from our group indicating a high frequency of multiple sclerosis (MS) could be confirmed. We soon identified an aggregation of MS cases in the parish of Lysvik located in the north of Värmland and initiated epidemiological and genetical analyses of the population. LÄS MER