Sökning: "E2F"
Visar resultat 1 - 5 av 21 avhandlingar innehållade ordet E2F.
1. Role of MYCN in retinoblastoma : From carcinogenesis to tumor progression
Sammanfattning : Retinoblastoma, a pediatric malignancy of the retina, is primarily driven by the bi-allelic inactivation of the RB1gene. However, a subset of cases are characterized by proficient RB1 functions but with MYCN copy number mutations, suggesting an alternative oncogenic mechanism in the absence of RB1 mutations. LÄS MER
2. Molecular characterization of type I endometrial carcinomas
Sammanfattning : Endometrial carcinoma is the most common malignancy in the female reproductive tract. In Sweden over 1300 women are diagnosed every year, and although the prognosis is favourable in the majority of cases, about 160 patients die of the disease every year. LÄS MER
3. Regulation of gene transcription by the thyroid hormone receptors
Sammanfattning : Thyroid hormone (TH) has important effects on postnatal development as well as on adult metabolic homeostasis. TH meditates its effects through different isoforms of the thyroid hormone receptors (TRs) encoded by the TRalpha and TRbeta genes, respectively. TRs belong to the nuclear hormone receptor superfamily. LÄS MER
4. Functional characterization of the alternative reading frame protein p14ARF
Sammanfattning : A deeper understanding of the molecular events underlying tumor development is a prerequisite for the design of novel and efficient therapies. Inactivation of the p53 and retinoblastoma (Rb) tumor suppressor pathways appears as a common theme in most malignant human tumors. LÄS MER
5. Infrared spectroscopic studies : from small molecules to large
Sammanfattning : Infrared light (IR) was first discovered by Friedrich Wilhelm Herschel in 1800. However, until 1940’s, molecular IR studies involved only water and small organic molecules, because of the long measurement times. LÄS MER