Sökning: "ribosome biogenesis"

Visar resultat 1 - 5 av 43 avhandlingar innehållade orden ribosome biogenesis.

  1. 1. Eukaryotic Ribosome Biogenesis : Focus on the function of the assembly factor Mrd1p

    Författare :Åsa Segerstolpe; Lars Wieslander; Susan Gerbi; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Ribosome biogenesis; nucleolus; pre-rRNA processing; RNA-binding proteins; Mrd1; Molecular Biology; molekylärbiologi;

    Sammanfattning : The ribosome, the protein factory of the cell, is essential for all life forms. The ribosome is a large RNA-protein machine. It is built in a complex, multi-step process that involves a large number of accessory trans-acting factors and the synthesis consumes a considerable part of the cellular energy. LÄS MER

  3. 2. Removal and Replacement of Ribosomal Proteins : Effects on Bacterial Fitness and Ribosome Function

    Författare :Christina Tobin; Dan I. Andersson; Richard Buckingham; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; ribosome; protein synthesis; ribosomal proteins; translation initiation; ribosome biogenesis; fitness costs; compensatory evolution; horizontal gene transfer; Microbiology; Mikrobiologi; Biochemistry; Biokemi; Mikrobiologi; Microbiology;

    Sammanfattning : Protein synthesis is a complex process performed by sophisticated cellular particles known as ribosomes. Although RNA constitutes the major structural and functional component, ribosomes from all kingdoms contain an extensive array of proteins with largely undefined functional roles. LÄS MER

  4. 3. Nucleolar Ribosome Assembly

    Författare :Fredrik Lackmann; Lars Wieslander; Denis Lafontaine; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Ribosome biogenesis; RNA; Nucleolus; Molecular Biology; molekylärbiologi;

    Sammanfattning : Ribosomes are macromolecular machines that are responsible for production of every protein in a living cell. Yet we do not know the details about how these machines are formed. The ribosome consists of four RNA strands and roughly 80 proteins that associate with each other in the nucleolus and form pre-ribosomal complexes. LÄS MER

  5. 4. Ribosome biogenesis during skeletal muscle hypertrophy

    Författare :Ferdinand von Walden; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Muscle adaptation to chronic resistance exercise (RE) is the result of a cumulative effect on gene expression and protein content. Following a bout of RE, muscle protein synthesis increases and, if followed by consecutive bouts (training), protein accretion and muscle hypertrophy develops. LÄS MER

  7. 5. Ribosomal RNA Modification Enzymes : Structural and functional studies of two methyltransferases for 23S rRNA modification in Escherichia coli

    Författare :Avinash S. Punekar; Maria Selmer; Martino Bolognesi; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Escherichia coli; ribosome biogenesis; ribosome assembly; ribosomal RNA; peptidyltransferase center; domain V; post-transcriptional modification; methyltransferases; S-adenosyl-methionine; RlmM; Cm2498; RlmJ; m6A2030; X-ray crystallography; substrate recognition; substrate specificity; catalytic mechanism; evolution; Biology with specialization in Structural Biology; Biologi med inriktning mot strukturbiologi; Biokemi; Biochemistry;

    Sammanfattning : Escherichia coli ribosomal RNA (rRNA) is post-transcriptionally modified by site-specific enzymes. The role of most modifications is not known and little is known about how these enzymes recognize their target substrates. LÄS MER