Sökning: "NCoR"

Hittade 4 avhandlingar innehållade ordet NCoR.

  1. 1. Regulation of gene transcription by the thyroid hormone receptors

    Författare :Maria Nygård; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Thyroid hormone receptors; T3; cell differentiation; gene regulation; E2F-1; Necdin; TRH; nTRE; RXR; NCoR; XAP-2;

    Sammanfattning : Thyroid hormone (TH) has important effects on postnatal development as well as on adult metabolic homeostasis. TH meditates its effects through different isoforms of the thyroid hormone receptors (TRs) encoded by the TRalpha and TRbeta genes, respectively. TRs belong to the nuclear hormone receptor superfamily. LÄS MER

  3. 2. Transcriptional regulation of neural development and degeneration

    Författare :Giulia Gaudenzi; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The architecture and functional interactions of the cerebral cortex are fascinating in their complexity of billions of neurons and glial cells connected in intricate circuitries and spatial regions. During development, transcription factors and chromatin modifiers work together to coordinate gene expression programs that drive the formation of the cerebral cortex. LÄS MER

  4. 3. Oxysterol receptors LXRs and coregulators in cholesterol metabolism and inflammatory transrepression pathways

    Författare :Tomas Jakobsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The LXRs are important sensors and regulators of cholesterol homeostasis in several metabolic tissues including liver, intestine and macrophages. They regulate target genes involved in cholesterol-, lipid- and carbohydrat metabolism. Recently, the LXRs have emerged as important regulators of the innate and adaptive immune system and inflammation. LÄS MER

  5. 4. Transcriptional regulation by the nuclear receptors steroidogenic factor-1 and liver receptor homologue-1

    Författare :Anna Ehrlund; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Steroidogenic Factor-1 (SF-1) and Liver Receptor Homologue-1 (LRH-1) are transcription factors belonging to the nuclear receptor (NR) family. In the adrenal cortex and gonads, SF-1 governs the expression of multiple enzymes and transporters required for converting cholesterol to steroid hormones. LÄS MER