Sökning: "p19ARF"

Hittade 4 avhandlingar innehållade ordet p19ARF.

  1. 1. Functional characterization of the alternative reading frame protein p14ARF

    Författare :Mikael Lindström; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :p14ARF; p19ARF; alternative reading frame; CDKN2A; p53; B23; nucleophosmin; Burkitt´s lymphoma; nucleolus; senescence; Myc; E2F; phosphorylation; RNA interference; ribosome biogenesis;

    Sammanfattning : A deeper understanding of the molecular events underlying tumor development is a prerequisite for the design of novel and efficient therapies. Inactivation of the p53 and retinoblastoma (Rb) tumor suppressor pathways appears as a common theme in most malignant human tumors. LÄS MER

  3. 2. Cellular Origin and Development of Glioma

    Författare :Nanna Lindberg; Lene Uhrbom; Bengt Westermark; Kristian Pietras; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Glioma; brain tumor; PDGF; RCAS TV-A; cell of origin; glial cell; oligodendrocyte progenitor cell; DNA repair; homology-directed repair; RAD51; angiogenesis; histidine-rich glycoprotein; Morphology; cell biology; pathology; Morfologi; cellbiologi; patologi; Molecular Medicine; molekylär medicin genetik och patologi ;

    Sammanfattning : Gliomas are the most common primary tumors of the central nervous system believed to arise from glial cells. Invasive growth and inherent propensity for malignant progression make gliomas incurable despite extensive treatment. LÄS MER

  4. 3. Vascular development and safeguard mechanisms against tumorigenesis : oncogene-induced apoptosis and cellular senescence

    Författare :Eduar Hejll; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Angiogenesis;

    Sammanfattning : Angiogenesis, apoptosis and senescence are all cellular processes that have an impact on tumor development. Angiogenesis or the new vessel formation from pre-existing ones is known to be required for invasive tumor growth and metastasis. LÄS MER

  5. 4. Targeting MYC and CDK2 in cancer : impacts on senescence, apoptosis and immune modulation

    Författare :Wesam Bazzar; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Cancer is a disease in which cells acquire the ability to divide uncontrollably and invade other tissues. An important component of this process is the activation of oncogenes and inactivation of tumor suppressor genes. LÄS MER